Simulation of Cardiac Flow under the Septal Defect Based on Lattice Boltzmann Method.
Simulation of Cardiac Flow under the Septal Defect Based on Lattice Boltzmann Method.
复制标题
基于格子玻尔兹曼法的室间隔缺损下心脏血流模拟
DOI：
10.3390/e24020187
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发表时间：
2022-01-27
期刊：
影响因子：
--
通讯作者：
Qian Y
中科院分区：
文献类型：
--
作者：
Wang Z;Zhang X;Li Y;Yang H;Xue H;Wei Y;Qian Y
本文采用点阵玻尔兹曼方法模拟无菌性缺陷患儿的心脏血流。通过210次计算机断层扫描重建心脏内壁模型。通过模拟和比较手术前后心脏流场、压力场、血氧含量、熵产分布，详细分析室间隔缺损对肺动脉高压（PH）、紫绀、心脏负荷的影响。我们分析的患儿房间隔缺损（房间隔缺损，atrial septal defect， ASD）对肺动脉血氧含量影响较大，导致肺氧结合效率降低，增加心脏负担。同时，它也显著增强了心流的熵产率，这也导致了更高的心脏负荷。然而，PH的主要原因不是ASD，而是室间隔缺损（VSD）。同时显著降低头臂干血氧含量，但对左颈总动脉下游、左锁骨下动脉及降主动脉的血氧含量影响不大。它会导致脸部和嘴唇出现严重的紫绀。
In this paper, the lattice Boltzmann method was used to simulate the cardiac flow in children with aseptal defect. The inner wall model of the heart was reconstructed from 210 computed tomography scans. By simulating and comparing the cardiac flow field, the pressure field, the blood oxygen content, and the distribution of entropy generation before and after an operation, the effects of septal defect on pulmonary hypertension(PH), cyanosis, and heart load were analyzed in detail. It is found that the atrial septal defect(ASD) of the child we analyzed had a great influence on the blood oxygen content in the pulmonary artery, which leads to lower efficiency of oxygen binding in the lungs and increases the burden on the heart. At the same time, it also significantly enhanced the entropy generation rate of the cardiac flow, which also leads to a higher heart load. However, the main cause of PH is not ASD, but ventricular septal defect (VSD). Meanwhile, it significantly reduced the blood oxygen content in the brachiocephalic trunk, but rarely affects the blood oxygen contents in the downstream left common carotid artery, left subclavian artery, and descending aorta are not significantly affected by VSD. It causes severe cyanosis on the face and lips.
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影响因子：
1.1
作者：
Alakhfash AA;Alqwaiee A;Alakhfash GA;Alhajjaj A;Almesned AA
通讯作者：
Almesned AA
影响因子：
2.4
作者：
He, XY;Shan, XW;Doolen, GD
通讯作者：
Doolen, GD
影响因子：
8.9
作者：
Schicchi, Nicolo;Fogante, Marco;Giovagnoni, Andrea
通讯作者：
Giovagnoni, Andrea
影响因子：
--
作者：
Conijn M;Krings GJ
通讯作者：
Krings GJ
DOI：
10.1098/rstb.2017.0330
发表时间：
2018-11-05
影响因子：
6.3
作者：
Courchaine, Katherine;Rugonyi, Sandra
通讯作者：
Rugonyi, Sandra