The glucose signaling network in yeast.
The glucose signaling network in yeast.
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DOI：
10.1016/j.bbagen.2013.07.025
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发表时间：
2013-11
影响因子：
3
通讯作者：
Cho, Kyu Hong
中科院分区：
文献类型：
--
作者：
Kim, Jeong-Ho;Roy, Adhiraj;Jouandot, David, II;Cho, Kyu Hong
大多数细胞都有一种复杂的机制来感知葡萄糖并对其做出适当的反应。芽殖酵母酿酒酵母中的葡萄糖传感和信号传导代表了理解细胞外信号如何导致真核生物基因表达程序变化的重要范例。本文综述了酵母葡萄糖传感和信号通路，在一个高度调节和合作的方式来实现葡萄糖诱导的HXT基因表达。酵母细胞具有一个葡萄糖转运蛋白（HXTs）家族，具有不同的动力学特性。它们采用三种主要的葡萄糖信号通路-Rgt 2/Snf 3，AMPK和cAMP-PKA-仅表达最适合葡萄糖可用量的转运蛋白。我们讨论了目前的理解，这些途径是如何整合到一个监管网络，以确保有效的摄取和利用葡萄糖。阐明参与酵母中葡萄糖摄取和代谢的多种葡萄糖信号和途径的作用可能揭示人类葡萄糖稳态的分子基础，特别是在病理条件下，如糖尿病患者的高血糖症和许多实体瘤中观察到的糖酵解速率升高。
Most cells possess a sophisticated mechanism for sensing glucose and responsing to it appropriately. Glucose sensing and signaling in the budding yeast Saccharomyces cerevisiae represents an important paradigm for understanding how extracellular signals lead to changes in the gene expression program in eukaryotes. This review focuses on the yeast glucose sensing and signaling pathways that operate in a highly regulated and cooperative manner to bring about glucose-induction of HXT gene expression. The yeast cells possess a family of glucose transporters (HXTs), with different kinetic properties. They employ three major glucose signaling pathways— Rgt2/Snf3, AMPK, and cAMP-PKA—to express only those transporters best suited for the amounts of glucose available. We discuss the current understanding of how these pathways are integrated into a regulatory network to ensure efficient uptake and utilization of glucose. Elucidating the role of multiple glucose signals and pathways involved in glucose uptake and metabolism in yeast may reveal the molecular basis of glucose homeostasis in humans, especially under pathological conditions, such as hyperglycemia in diabetics and the elevated rate of glycolysis observed in many solid tumors.
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影响因子：
30.8
作者：
Buck, Michael J.;Lieb, Jason D.
通讯作者：
Lieb, Jason D.
影响因子：
3.7
作者：
Hanlon SE;Rizzo JM;Tatomer DC;Lieb JD;Buck MJ
通讯作者：
Buck MJ
影响因子：
3.2
作者：
GAMO, FJ;LAFUENTE, MJ;GANCEDO, C
通讯作者：
GANCEDO, C
DOI：
10.1073/pnas.88.19.8597
发表时间：
1991-10-01
影响因子：
11.1
作者：
GRIGGS, DW;JOHNSTON, M
通讯作者：
JOHNSTON, M
影响因子：
4.1
作者：
Crabtree, HG
通讯作者：
Crabtree, HG