Bacterial endotoxin activity in human serum is associated with dyslipidemia, insulin resistance, obesity, and chronic inflammation.
Bacterial endotoxin activity in human serum is associated with dyslipidemia, insulin resistance, obesity, and chronic inflammation.
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DOI：
10.2337/dc10-2197
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发表时间：
2011-08
期刊：
影响因子：
16.2
通讯作者：
FinnDiane Study Group
中科院分区：
文献类型：
--
作者：
Lassenius MI;Pietiläinen KH;Kaartinen K;Pussinen PJ;Syrjänen J;Forsblom C;Pörsti I;Rissanen A;Kaprio J;Mustonen J;Groop PH;Lehto M;FinnDiane Study Group
目的：探讨1型糖尿病合并不同程度肾脏疾病和IgA肾小球肾炎患者血清细菌脂多糖(LPS)活性与代谢综合征(METS)成分的关系。用凝胶显色终点法测定白蛋白排泄率正常的1型糖尿病患者(587例)、微量白蛋白尿组(144例)、大量白蛋白尿组(173例)、IgAGN组(98例)和非糖尿病对照组(345例)的血清内毒素活性。用Pearson相关分析法评价内毒素/高密度脂蛋白比值与Mets相关变量之间的关系。甲硫氨酸转运蛋白在1型糖尿病患者中的发生率(48%)高于IgAGN患者(15%)。糖尿病伴大量白蛋白尿患者的血清脂多糖/高密度脂蛋白比值显著高于IgAGN患者。在正常白蛋白尿1型糖尿病组中，内毒素/高密度脂蛋白四分位数最高的患者被诊断为METS的频率是最低四分位数的患者的三倍(69vs.22%；P<；0.001)。高内毒素活性与较高的血清甘油三酯浓度、较早的糖尿病发病、舒张压升高和尿单核细胞趋化蛋白-1排泄量增加有关。血清高内毒素活性与蛋氨酸的成分密切相关。糖尿病肾病患者似乎比IgAGN患者更易患代谢性内毒素血症。因此，细菌内毒素可能在肥胖和糖尿病相关疾病中常见的代谢和血管异常的发展中发挥重要作用。
To investigate whether bacterial lipopolysaccharide (LPS) activity in human serum is associated with the components of the metabolic syndrome (MetS) in type 1 diabetic patients with various degrees of kidney disease and patients with IgA glomerulonephritis (IgAGN). Serum LPS activity was determined with the Limulus Amoebocyte Lysate chromogenic end point assay in type 1 diabetic patients with a normal albumin excretion rate (n = 587), microalbuminuria (n = 144), macroalbuminuria (n = 173); patients with IgAGN (n = 98); and in nondiabetic control subjects (n = 345). The relationships of the LPS/HDL ratio and MetS-associated variables were evaluated with Pearson correlation. The MetS was more prevalent in type 1 diabetic patients (48%) than in patients with IgAGN (15%). Diabetic patients with macroalbuminuria had a significantly higher serum LPS/HDL ratio than patients with IgAGN. In the normoalbuminuric type 1 diabetic group, patients in the highest LPS/HDL quartile were diagnosed as having the MetS three times more frequently than patients in the lowest quartile (69 vs. 22%; P < 0.001). High LPS activity was associated with higher serum triglyceride concentration, earlier onset of diabetes, increased diastolic blood pressure, and elevated urinary excretion of monocyte chemoattractant protein-1. High serum LPS activity is strongly associated with the components of the MetS. Diabetic patients with kidney disease seem to be more susceptible to metabolic endotoxemia than patients with IgAGN. Bacterial endotoxins may thus play an important role in the development of the metabolic and vascular abnormalities commonly seen in obesity and diabetes-related diseases.
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影响因子：
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