Hydrophilic modifications of an amphiphilic polynorbornene and the effects on its hemolytic and antibacterial activity.
Hydrophilic modifications of an amphiphilic polynorbornene and the effects on its hemolytic and antibacterial activity.
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DOI：
10.1021/bm801129y
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发表时间：
2009-02-09
影响因子：
6.2
通讯作者：
Tew, Gregory N.
中科院分区：
文献类型：
--
作者：
Colak, Semra;Nelson, Christopher F.;Nusslein, Klaus;Tew, Gregory N.
在这里，我们报告的修改的两亲性抗菌聚苯乙烯，聚3，通过纳入亲水性，生物相容性基团。糖，两性离子，和聚乙二醇为基础的部分被纳入不同的比例通过共聚和后聚合技术。得到分子量为3 kDa和窄的多分散指数从1.08到1.15的定义明确的共聚物。通过测定它们的最小抑制浓度（MIC）和它们的溶血活性（HC 50）来分析这些修饰对这些聚合物的生物活性的影响。
Here, we report the modification of an amphiphilic antibacterial polynorbornene, Poly3, via incorporation of hydrophilic, biocompatible groups. The sugar, zwitterionic, and polyethylene glycol based moieties were incorporated in varying ratios by copolymerization and post-polymerization techniques. Well-defined copolymers with molecular weights of 3 kDa and narrow polydispersity indices from 1.08 to 1.15 were obtained. The effects of these modifications on the biological activity of these polymers were analyzed by determining their minimum inhibitory concentrations (MIC) and their hemolytic activities (HC50).
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