Parental socioeconomic position and midlife allostatic load: a study of potential mediators.
Parental socioeconomic position and midlife allostatic load: a study of potential mediators.
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DOI：
10.1186/s12889-018-5956-x
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发表时间：
2018-08-20
影响因子：
4.5
通讯作者：
Mortensen EL
中科院分区：
文献类型：
--
作者：
Christensen DS;Flensborg-Madsen T;Garde E;Hansen ÅM;Pedersen JM;Mortensen EL
父母的社会经济地位与晚年生活的非稳态负荷之间的联系机制尚不清楚。本研究旨在探讨这种关联的潜在途径：人格，社会关系，智力和教育。该研究包括哥本哈根围产期队列的361名成员，他们参加了随后的两项随访：产前发育项目（平均年龄27岁）和哥本哈根老龄化和中年生物银行研究（平均年龄50岁）。非稳态负荷是基于14个生物标志物代表炎症，代谢和心血管系统在中年测量。潜在的介质的信息收集在年轻的成年人，他们的作用与父母的社会经济地位与中年非稳态负荷的关联进行了研究，在线性回归路径分析。一岁时父母的社会经济地位与中年非稳态负荷呈负相关（β =-0.238，p < .001）。没有发现人格或社会关系的中介作用。在一个包括智力和教育的模型中，发现教育对智力有显著的间接影响（β =-0.151，p < .001）。一个显著的直接效应仍然存在（β =-0.111，p = 0.040）。父母的社会经济地位与中年的非稳态负荷呈负相关。结果表明，这种关联的一部分是由教育介导的。更好地了解与教育有关的非认知途径是制定有效干预战略的重要前提。本文的在线版本（10.1186/s12889-018-5956-x）包含补充材料，可供授权用户使用。
The mechanisms underlying the association of parental socioeconomic position with later life allostatic load remain unclear. The present study aims to examine potential pathways underlying this association: personality, social relations, intelligence and education. The study comprised 361 members of the Copenhagen Perinatal Cohort who participated in two subsequent follow-ups: the Prenatal Development Project (mean age 27 years) and the Copenhagen Aging and Midlife Biobank study (mean age 50 years). Allostatic load was based on 14 biomarkers representing the inflammatory, metabolic and cardiovascular system measured at midlife. Information on potential mediators was collected in young adulthood, and their role in the association of parental socioeconomic position with midlife allostatic load were examined in linear regression path analyses. Parental socioeconomic position at one year was inversely associated with midlife allostatic load (β = − 0.238, p < .001). No mediation effects were found for personality or social relations. In a model including intelligence and education, a significant indirect effect was found for education (β = − 0.151, p < .001). A significant direct effect remained (β = − 0.111, p = .040). Parental socioeconomic position was inversely associated with allostatic load in midlife. Results suggest that part of this association was mediated by education. A better understanding of the non-cognitive pathways related to education is an important prerequisite for the development of effective intervention strategies. The online version of this article (10.1186/s12889-018-5956-x) contains supplementary material, which is available to authorized users.
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影响因子：
8.2
作者：
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通讯作者：
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影响因子：
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DOI：
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期刊：
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