Antiallergic effect of ardisiaquinone A, a potent 5-lipoxygenase inhibitor.
Antiallergic effect of ardisiaquinone A, a potent 5-lipoxygenase inhibitor.
复制标题
紫金牛醌 A 的抗过敏作用，一种有效的 5-脂氧合酶抑制剂。
DOI：
10.1078/s0944-7113(04)70065-3
复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
M. Akagi
中科院分区：
文献类型：
--
作者：
N. Fukuishi;T. Takada;Y. Fukuyama;M. Akagi
研究了紫金牛醌 A（一种有效的 5-脂氧合酶抑制剂）的抗过敏作用。用紫金牛醌 A (0.1-10 microM) 预处理可显着抑制化合物 48/80 诱导的大鼠腹膜肥大细胞中半胱氨酰白三烯（cys-LT；LTC4、LTD4 和 LTE4）的产生，但不抑制组胺的释放。 IC50值为5.56μM。预先给予紫金牛醌 A (0.1-1 mg/kg, s.c.) 剂量依赖性地抑制大鼠同源被动皮肤过敏反应 (PCA)，在 1 mg/kg 剂量时最大抑制率为 22.3 +/- 3.9%。 Ardisiaquinone A (1-5 mg/kg, s.c.) 剂量依赖性地防止卵清蛋白致敏豚鼠中过敏原引起的气管压力增加，尤其是在晚期。总之，本研究的结果表明，5-脂氧合酶抑制剂紫金牛醌 A 通过抑制肥大细胞中 cys-LT 的产生，部分减弱过敏原诱导的血管通透性和气管压力的增加。
The antiallergic effects of ardisiaquinone A, a potent 5-lipoxygenase inhibitor, were examined. Pretreatment with ardisiaquinone A (0.1-10 microM) significantly inhibited compound 48/80-induced production of cysteinyl-leukotrienes (cys-LTs; LTC4, LTD4 and LTE4) in rat peritoneal mast cells, but not histamine release. The IC50 value was 5.56 microM. Pre-administration with ardisiaquinone A (0.1-1 mg/kg, s.c.) dose-dependently inhibited rat homologous passive cutaneous anaphylaxis (PCA) and the maximal inhibitory ratio was 22.3 +/- 3.9% at the dose of 1 mg/kg. Ardisiaquinone A (1-5 mg/kg, s.c.) dose-dependently prevented the allergen-induced increase of tracheal pressure in ovalbumin-sensitized guinea pigs, especially during the late phase. In conclusion, the findings of this study show that 5-lipoxygenase inhibitor ardisiaquinone A partially attenuates the allergen-induced increases of vascular permeability and tracheal pressure via the inhibition of cys-LTs production in mast cells.
DOI：
10.1164/ajrccm/143.5_pt_2.s86
发表时间：
1991-05-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
HENDERSON, WR
通讯作者：
HENDERSON, WR