Prompt-gamma compensation in Rb-82 myocardial perfusion 3D PET/CT
Prompt-gamma compensation in Rb-82 myocardial perfusion 3D PET/CT
复制标题
Rb-82 心肌灌注 3D PET/CT 中的即时伽玛补偿
DOI：
10.1007/s12350-009-9170-1
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发表时间：
2010
影响因子：
2.4
通讯作者：
J. Votaw
中科院分区：
文献类型：
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作者：
F. Esteves;J. Nye;Akbar Khan;R. Folks;R. Halkar;Ernest V. Garcia;D. Schuster;S. Lerakis;P. Raggi;J. Votaw
目的比较Rb-82心肌灌注三维（3D）PET在有和无PGC时的诊断准确性。方法和结果回顾性、单中心研究76例患者，均进行了静息和腺苷负荷Rb-82心肌灌注3D PET。所有研究均使用Siemens Biograph-40 PET/CT扫描仪进行采集，并在有和无PGC的情况下进行重建。57名患者（平均年龄63 ± 11岁，26名男性）在Rb-82成像后40天内进行了冠状动脉造影。19例患者（平均年龄43 ± 7岁，10例男性）冠状动脉疾病（CAD）的可能性较低。所有PET图像均由两名盲法阅片者采用17节段左心室模型，在标准5分量表上一致评分。正常的PET测试被定义为总压力评分小于4。冠状动脉造影时的阻塞性CAD被用作金标准，定义为一条或多条主要冠状动脉的管腔狭窄≥50%。冠状动脉造影显示梗阻性病变的患病率为68%（39/57）。PGC图像的平均总应激评分为12 ± 12，非PGC图像的平均总应激评分为18 ± 14。结论Rb-82 3D PET中的PGC可提高冠状动脉造影诊断冠心病的特异性，但敏感性无明显降低。
ObjectiveTo compare the diagnostic accuracy of Rb-82 myocardial perfusion three-dimensional (3D) PET with and without prompt-gamma compensation (PGC).Methods and resultsRetrospective, single center study of 76 patients who had rest and adenosine stress Rb-82 myocardial perfusion 3D PET. All studies were acquired using a Siemens Biograph-40 PET/CT scanner and were reconstructed with and without PGC. Fifty-seven patients (mean age 63 ± 11 years, 26 men) had coronary angiography within 40 days of Rb-82 imaging. Nineteen patients (mean age 43 ± 7 years, 10 men) had low likelihood of coronary artery disease (CAD). All PET images were scored by consensus of two blinded readers on a standard 5-point scale using a 17-segment left ventricular model. A normal PET test was defined as a summed stress score of less than four. Obstructive CAD at coronary angiography was used as the gold-standard and was defined as luminal stenoses ≥50% in one or more major coronary arteries. The prevalence of obstructive disease at coronary angiography was 68% (39/57). The mean summed stress score was 12 ± 12 for PGC images and was 18 ± 14 for non-PGC images. Sensitivity and specificity for obstructive CAD were 90% (95% CI 88-99) and 72% (95% CI 52-93) for PGC images and 95% (95% CI 88-100) and 22% (95% CI 3-41) for non-PGC images.ConclusionPGC in Rb-82 3D PET improves the specificity for obstructive CAD at coronary angiography with no significant loss in sensitivity.
定量当天休息压力 technetium-99m-sestamibi SPECT：压力正常限度和异常标准的定义和验证。
DOI：
--
发表时间：
1993
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
VanTrain,KF;Areeda,J;Garcia,EV;Cooke,CD;Maddahi,J;Kiat,H;Germano,G;Silagan,G;Folks,R;Berman,DS
通讯作者：
Berman,DS
影响因子：
2.8
作者：
STEWART, RE;SCHWAIGER, M;KUHL, DE
通讯作者：
KUHL, DE
影响因子：
3.8
作者：
Beattie, BJ;Finn, RD;Pentlow, KS
通讯作者：
Pentlow, KS