Multi-receptor detection of individual bacterial products by the innate immune system.
Multi-receptor detection of individual bacterial products by the innate immune system.
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DOI：
10.1038/nri.2017.25
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发表时间：
2017-06
期刊：
影响因子：
--
通讯作者：
Kagan JC
中科院分区：
文献类型：
--
作者：
Kieser KJ;Kagan JC
先天免疫系统的受体检测特定的微生物配体，以促进有效的炎症和适应性免疫反应。尽管这个想法得到了广泛认可，但近年来的研究强调了先天免疫检测的复杂性，多个宿主受体识别相同的微生物配体。了解识别常见微生物特征的不同受体的集体行为代表了先天免疫研究的新领域，也是本综述的重点。在这里，我们讨论了被先天免疫系统的至少两种和多达四种不同受体识别的单个细菌细胞壁成分的例子。这些受体调查细胞外或胞质空间中的同源配体，并以互补的方式起作用以诱导不同的细胞反应。我们进一步强调，尽管受体和途径存在遗传多样性，但存在解释这些受体运作的共同特征。这些共同特征可能有助于提供与主机防御相关的统一组织原则。
The receptors of the innate immune system detect specific microbial ligands to promote effective inflammatory and adaptive immune responses. Although this idea is well appreciated, studies in recent years have highlighted the complexity of innate immune detection, with multiple host receptors recognizing the same microbial ligand. Understanding the collective actions of diverse receptors that recognize common microbial signatures represents a new frontier in the study of innate immunity, and is the focus of this Review. Here, we discuss examples of individual bacterial cell wall components that are recognized by at least two and as many as four different receptors of the innate immune system. These receptors survey the extracellular or cytosolic spaces for their cognate ligands and operate in a complementary manner to induce distinct cellular responses. We further highlight that, despite this genetic diversity in receptors and pathways, common features exist to explain the operation of these receptors. These common features may help to provide unifying organizing principles associated with host defence.
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