Clocking cancer: the circadian clock as a target in cancer therapy.
Clocking cancer: the circadian clock as a target in cancer therapy.
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DOI：
10.1038/s41388-021-01778-6
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发表时间：
2021-05
期刊：
影响因子：
8
通讯作者：
Lenz HJ
中科院分区：
文献类型：
--
作者：
Battaglin F;Chan P;Pan Y;Soni S;Qu M;Spiller ER;Castanon S;Roussos Torres ET;Mumenthaler SM;Kay SA;Lenz HJ
调节内源性24小时节律的细胞途径（称为“昼夜节律钟”）的破坏最近已被证明与癌症风险，发展和进展有关。该途径通过由一组相互作用的蛋白质产生的转录-翻译反馈环的复杂网络来运作。核心生物钟基因的表达在人类肿瘤中经常失调;然而，具体的影响和潜在的机制似乎因癌症类型而异，并且尚未完全了解。此外，特定的癌基因可能差异诱导肿瘤的昼夜节律钟失调。生物钟成分的药理学调节已被证明在某些类型的癌细胞中导致特异性致死，因此作为一种新型抗癌治疗方法具有很大的前景。在这里，我们概述了在癌症治疗中靶向生物钟的基本原理和现有证据。
Disruption of the cellular pathway modulating endogenous 24-hour rhythms, referred to as ‘the circadian clock’, has been recently proven to be associated with cancer risk, development and progression. This pathway operates through a complex network of transcription-translation feedback loops generated by a set of interplaying proteins. The expression of core circadian clock genes is frequently dysregulated in human tumors; however, the specific effects and underlying mechanisms seem to vary depending on the cancer types and are not fully understood. Additionally, specific oncogenes may differentially induce the dysregulation of the circadian clock in tumors. Pharmacological modulation of clock components has been shown to result in specific lethality in certain types of cancer cells, and thus holds great promise as a novel anti-cancer therapeutic approach. Here we present an overview of the rationale and current evidence for targeting the clock in cancer treatment.
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影响因子：
8
作者：
De Mei C;Ercolani L;Parodi C;Veronesi M;Lo Vecchio C;Bottegoni G;Torrente E;Scarpelli R;Marotta R;Ruffili R;Mattioli M;Reggiani A;Wade M;Grimaldi B
通讯作者：
Grimaldi B
影响因子：
11.1
作者：
Burgermeister, Elke;Battaglin, Francesca;Ebert, Matthias P.
通讯作者：
Ebert, Matthias P.
DOI：
10.1073/pnas.0811410106
发表时间：
2008-12-30
影响因子：
11.1
作者：
Hirota, Tsuyoshi;Lewis, Warren G.;Kay, Steve A.
通讯作者：
Kay, Steve A.
影响因子：
50.3
作者：
Kettner NM;Voicu H;Finegold MJ;Coarfa C;Sreekumar A;Putluri N;Katchy CA;Lee C;Moore DD;Fu L
通讯作者：
Fu L
MYC破坏了癌细胞中的昼夜节律和代谢。
影响因子：
29
作者：
Altman BJ;Hsieh AL;Sengupta A;Krishnanaiah SY;Stine ZE;Walton ZE;Gouw AM;Venkataraman A;Li B;Goraksha-Hicks P;Diskin SJ;Bellovin DI;Simon MC;Rathmell JC;Lazar MA;Maris JM;Felsher DW;Hogenesch JB;Weljie AM;Dang CV
通讯作者：
Dang CV