Macrophage Trafficking, Inflammatory Resolution, and Genomics in Atherosclerosis: JACC Macrophage in CVD Series (Part 2).
Macrophage Trafficking, Inflammatory Resolution, and Genomics in Atherosclerosis: JACC Macrophage in CVD Series (Part 2).
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DOI：
10.1016/j.jacc.2018.08.2147
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发表时间：
2018-10-30
影响因子：
24
通讯作者：
Kovacic JC
中科院分区：
文献类型：
--
作者：
Moore KJ;Koplev S;Fisher EA;Tabas I;Björkegren JLM;Doran AC;Kovacic JC
Atherosclerosis is characterized by the retention of modified lipoproteins in the arterial wall. These modified lipoproteins activate resident macrophages, and the recruitment of monocyte-derived cells, which differentiate into mononuclear phagocytes that ingest the deposited lipoproteins to become “foam cells”; a hallmark of this disease. In this part 2 of a 4-part review series covering the macrophage in cardiovascular disease, we critically review the contributions and relevant pathobiology of monocytes, macrophages and foam cells as relevant to atherosclerosis. We also review evidence that via various pathways, a failure of the resolution of inflammation is an additional key aspect of this disease process. Finally, we consider the likely role played by genomics and biologic networks in controlling the macrophage phenotype in atherosclerosis. Collectively, these data provide substantial insights on the atherosclerotic process, while concurrently offering numerous molecular and genomic candidates that appear to hold great promise for selective targeting as clinical therapies. Atherosclerosis is characterized by the retention of modified lipoproteins in the arterial wall. These modified lipoproteins activate resident macrophages, and the recruitment of monocyte-derived cells, which differentiate into mononuclear phagocytes that ingest the deposited lipoproteins to become “foam cells”; a hallmark of this disease. In this second of a 4-part review series we consider the contributions and pathobiology of monocytes, macrophages and foam cells as relevant to atherosclerosis. We also review evidence that failure of inflammation resolution is a key aspect of this disease, and also the role of genomics and biologic networks in controlling the macrophage phenotype in atherosclerosis.
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DOI：
10.4049/jimmunol.1602175
发表时间：
2017-06-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Aziz MH;Cui K;Das M;Brown KE;Ardell CL;Febbraio M;Pluskota E;Han J;Wu H;Ballantyne CM;Smith JD;Cathcart MK;Yakubenko VP
通讯作者：
Yakubenko VP
影响因子：
15.9
作者：
Fadok, VA;Bratton, DL;Henson, PM
通讯作者：
Henson, PM
DOI：
10.1073/pnas.1524292113
发表时间：
2016-06-07
影响因子：
11.1
作者：
Cai, Bishuang;Thorp, Edward B.;Tabas, Ira
通讯作者：
Tabas, Ira
具有遗传转换的高脂血症的逆转会影响动脉粥样硬化斑块中巨噬细胞的含量和炎症状态。
影响因子：
37.8
作者：
Feig JE;Parathath S;Rong JX;Mick SL;Vengrenyuk Y;Grauer L;Young SG;Fisher EA
通讯作者：
Fisher EA
影响因子：
37.8
作者：
Combadiere, Christophe;Potteaux, Stephane;Mallat, Ziad
通讯作者：
Mallat, Ziad