Cardiovascular effects of losartan and its relevant clinical application.
Cardiovascular effects of losartan and its relevant clinical application.
复制标题
DOI：
10.2174/092986709789178046
复制
发表时间：
2009
影响因子：
4.1
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Xu F;Mao C;Hu Y;Rui C;Xu Z;Zhang L
肾素-血管紧张素系统（RAS）在维持心血管系统的稳态和心血管疾病的发生发展中起着重要作用。心脏和血管系统局部RAS的异常表达或过度激活是心血管疾病病理生理过程中最常见的机制之一。这也为使用化学方法进行医学预防和治疗提供了基础。氯沙坦是一种选择性的血管紧张素Ⅱ 1型受体（AT 1 R）非肽类拮抗剂，已被应用于包括原发性高血压在内的多种心血管疾病的治疗。本文就氯沙坦对心脏和血管的直接和间接心血管作用作一综述。它总结了氯沙坦的作用位点的AT 1 R的化学基础，着重于氯沙坦在心脏和血管系统中的作用机制，并回顾了可能有助于开发新的化学候选物或方法的信息。
The renin-angiotensin system (RAS) plays an important role in the homeostasis of the cardiovascular system and in the development of cardiovascular diseases. An abnormal expression or over activation of the local RAS in the heart and vasculature system is one of the most common mechanisms in pathophysiological processes in cardiovascular diseases. This also provides a basis for medical prevention and treatments using chemical approaches. Losartan is a selective nonpeptite antagonist against type 1 angiotensin II receptors (AT1R), and has been applied in medical treatments of a variety of cardiovascular diseases, including essential hypertension. This article reviews direct and indirect cardiovascular effects of losartan on the heart and blood vessels. It summarizes the chemical basis of AT1R for the action site of losartan, focuses on the mechanisms underlying the action of losartan involved in both the heart and vasculature, and reviews the information that may be helpful in the development of new chemical candidates or approaches in the war against cardiovascular diseases.
登录
查看更多内容
心肌梗塞会增加大鼠和人类 ACE2 的表达
影响因子：
39.3
作者：
Burrell, LM;Risvanis, J;Johnston, CI
通讯作者：
Johnston, CI
影响因子：
37.8
作者：
Caballero, R;Delpón, E;Tamargo, J
通讯作者：
Tamargo, J
影响因子：
6.1
作者：
Andersen, S;Rossing, P;Parving, HH
通讯作者：
Parving, HH
影响因子：
3.1
作者：
Aso, Yoshimasa
通讯作者：
Aso, Yoshimasa
DOI：
10.1152/ajpheart.1994.267.5.h1777
发表时间：
1994-11-01
影响因子：
4.8
作者：
ARNAL, JF;BATTLE, T;ALHENCGELAS, F
通讯作者：
ALHENCGELAS, F