Intracerebral Synthesis of Tumor Necrosis Factor‐α and Interleukin‐6 in Infectious Meningitis a
Intracerebral Synthesis of Tumor Necrosis Factor‐α and Interleukin‐6 in Infectious Meningitis a
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感染性脑膜炎 a 中肿瘤坏死因子-α 和白细胞介素-6 的脑内合成
DOI：
10.1111/j.1749-6632.1990.tb40491.x
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发表时间：
1990
影响因子：
5.2
通讯作者：
A. Fontana
中科院分区：
文献类型：
--
作者：
K. Frei;D. Nadal;A. Fontana
急性细菌性和病毒性脑膜炎仍然是世界范围内相对常见的疾病。奇怪的是，尽管抗生素的引入和持续改进，以及内毒素休克和血管衰竭的液体管理取得了进展，但主要在细菌性脑膜炎中观察到的病死率和永久性神经系统后遗症的风险在30年内没有改变。此外，脑膜炎的病因学的建立仍然是困难的。用于检测病原体的血液和脑脊液（CSF）培养的缺点是需要时间才能呈阳性。此外，CSF中细胞计数和蛋白质及葡萄糖浓度的测量可能并不总是绝对诊断的，因为细菌性脑膜炎的数据范围与病毒性脑膜炎的数据范围明显重叠。为了诊断原因和理解脑膜炎的持续和过程，CSF中各种在炎症中起作用的细胞因子的存在的研究可能是重要的。在这篇综述中，我们描述了鞘内产生肿瘤坏死因子-a（TNF-α）和白细胞介素-6（IL-6）的证明。虽然TNF-α已显示在败血性休克中的组织损伤中起致病作用：IL-6被认为有助于B淋巴细胞和浆细胞产生抗体。
Acute bacterial and viral meningitis remain relatively common diseases worldwide. Paradoxically, the case fatality rate and the risk of permanent neurologic sequelae being observed mainly in bacterial meningitis have not changed over 30 years despite the introduction of and continued improvement in antibiotics and despite the progress made on management with fluids of endotoxic shock and vascular failure.’” Furthermore, the establishment of the etiology of meningitis can still be difficult. Cultures of blood and cerebrospinal fluid (CSF) for detection of the etiologic agent have the drawback of the time required to become positive. Furthermore, measurements of cell counts and concentrations of protein and glucose in the CSF may not always be absolutely diagnostic as the ranges of the data in bacterial meningitis overlap significantly with those in viral meningiti~.~. For diagnostic reasons and for the understanding of the perpetuation and course of meningitis investigations of CSF for the presence of various cytokines that play a role in inflammation may be important. In this review, we describe the demonstration of intrathecal production of tumor necrosis factor-a (TNF-a) and interleukin-6 (IL-6). While TNF-a has been shown to play a pathogenic role in tissue injury in septic shock: IL-6 is suggested to contribute to production of antibodies by B lymphocytes and plasma cells.’
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影响因子：
158.5
作者：
MICHIE, HR;MANOGUE, KR;WILMORE, DW
通讯作者：
WILMORE, DW
影响因子：
4.4
作者：
J. Pober;M. Gimbrone;L. Lapierre;D. Mendrick;W. Fiers;R. Rothlein;T. Springer
通讯作者：
J. Pober;M. Gimbrone;L. Lapierre;D. Mendrick;W. Fiers;R. Rothlein;T. Springer
DOI：
10.1073/pnas.82.24.8667
发表时间：
1985-12-01
影响因子：
11.1
作者：
GAMBLE, JR;HARLAN, JM;VADAS, MA
通讯作者：
VADAS, MA
影响因子：
4.4
作者：
D. Helfgott;S. Tatter;U. Santhanam;R. H. Clarick;N. Bhardwaj;L. May;P. Sehgal
通讯作者：
D. Helfgott;S. Tatter;U. Santhanam;R. H. Clarick;N. Bhardwaj;L. May;P. Sehgal
受刺激的星形胶质细胞产生少突胶质细胞的细胞毒性因子。
DOI：
--
发表时间：
1987
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Robbins,DS;Shirazi,Y;Drysdale,BE;Lieberman,A;Shin,HS;Shin,ML
通讯作者：
Shin,ML