Increased serum clearance and degradation of 125I-labeled IGF-I in protein-restricted rats.
Increased serum clearance and degradation of 125I-labeled IGF-I in protein-restricted rats.
复制标题
蛋白质限制大鼠中 125I 标记的 IGF-I 的血清清除率和降解增加。
DOI：
10.1152/ajpendo.1992.262.4.e406
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Underwood,LE
中科院分区：
文献类型：
--
作者：
Thissen,JP;Davenport,ML;Pucilowska,JB;Miles,MV;Underwood,LE
Dietary protein restriction in young rats stunts growth and decreases serum insulin-like growth factor I (IGF-I) concentrations. To investigate the possibility of a diet-induced accelerated clearance of IGF-I, the clearance of 125I-labeled IGF-I was determined by measuring the radioactivity in serum obtained at different intervals after bolus injection in 5-wk-old rats that had received either a normal 15% protein diet (P15; n = 6) or a 5% protein isocaloric diet (P5; n = 7) for 1 wk. The clearance and volume of distribution of 125I-IGF-I were increased in P5 rats by 58 and 75%, respectively, whereas the terminal elimination half-life was not changed. The calculated IGF-I production rate was decreased by 40% in P5 rats. The intermediate distribution phase (alpha) was twofold faster in P5 than in P15 animals, and 125I-IGF-I was preferentially bound to IGF binding proteins in the 40-kDa complex in P5 rats. These observations might explain the increased clearance and degradation of IGF-I in the P5 rats. Dietary protein restriction appears to lower serum IGF-I concentrations by both decreasing its production rate and increasing its clearance.
影响因子：
4
作者：
BORNFELDT, KE;ARNQVIST, HJ;NORSTEDT, G
通讯作者：
NORSTEDT, G