Acute pain-related depression of operant responding maintained by social interaction or food in male and female rats.
Acute pain-related depression of operant responding maintained by social interaction or food in male and female rats.
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DOI：
10.1007/s00213-021-06048-7
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发表时间：
2022-02
影响因子：
3.4
通讯作者：
Negus, S. Stevens
中科院分区：
文献类型：
--
作者：
Baldwin, A. N.;Banks, M. L.;Marsh, S. A.;Townsend, E. A.;Venniro, M.;Shaham, Y.;Negus, S. Stevens
临床相关疼痛与功能障碍和行为抑郁（包括社交行为抑郁）有关。此外，功能恢复是疼痛治疗的主要目标。我们使用最近开发的大鼠社交互动操作反应模型来评估社交行为对实验性疼痛操纵的脆弱性以及疼痛抑制的社交行为对临床有效镇痛药治疗的敏感性。 Sprague-Dawley 雄性和雌性大鼠经过训练，利用杠杆压力与另一只大鼠进行社交接触，并在使用以下方法治疗后评估反应：(a) 腹腔注射稀乳酸（IP 酸；0.18–5.6%）单独作为内脏伤害性刺激，(b) mu-阿片受体 (MOR) 激动剂吗啡 (0.32–10 mg/kg) 或非甾体抗炎药(NSAID) 单独给予酮洛芬 (10 mg/kg)，或 (c) 在 IP 酸之前给予吗啡或酮洛芬。为了进行比较，在经过训练的不同老鼠中评估了相同的治疗方法，这些老鼠经过训练，按下杠杆来输送食物。单独的IP酸和单独的吗啡都比食物更能有效地降低社交互动维持的反应，而酮洛芬不影响这两种强化剂的反应。一般来说，当相对较低的 IP 酸浓度产生显着但次最大的行为抑制时，镇痛药对挽救操作反应最有效。然而，吗啡并不能有效地挽救社交互动反应。与食物维持的操作反应相比，通过社交互动维持的操作反应对疼痛相关的干扰更敏感，并且对阿片类镇痛药物的反应不太敏感。社会行为可能特别容易因疼痛状态而受到抑郁的影响。
Clinically relevant pain is associated with functional impairment and behavioral depression, including depression of social behavior. Moreover, recovery of function is a major goal in pain treatment. We used a recently developed model of operant responding for social interaction in rats to evaluate the vulnerability of social behavior to an experimental pain manipulation and the sensitivity of pain-depressed social behavior to treatment with clinically effective analgesics. Sprague-Dawley male and female rats were trained to lever press for social access to another rat, and responding was evaluated after treatment with (a) intraperitoneal injection of dilute lactic acid (IP acid; 0.18–5.6%) administered alone as a visceral noxious stimulus, (b) the mu-opioid receptor (MOR) agonist morphine (0.32–10 mg/kg) or nonsteroidal anti-inflammatory drug (NSAID) ketoprofen (10 mg/kg) administered alone, or (c) morphine or ketoprofen administered before IP acid. For comparison, the same treatments were evaluated in separate rats trained to lever press for food delivery. Both IP acid alone and morphine alone more potently decreased responding maintained by social interaction than by food, whereas ketoprofen did not affect responding for either reinforcer. In general, analgesics were most effective to rescue operant responding when relatively low IP acid concentrations produced significant but submaximal behavioral depression; however, morphine was not effective to rescue responding for social interaction. Operant responding maintained by social interaction was more sensitive to pain-related disruption and less responsive to opioid analgesic rescue than food-maintained operant responding. Social behavior may be especially vulnerable to depression by pain states.
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炎症引起的大鼠炎症引起的家用笼子抑制的分析揭示了阿片类药物抗伤害感和功能恢复之间的差异。
影响因子：
2.7
作者：
Kandasamy, Ram;Calsbeek, Jonas J.;Morgan, Michael M.
通讯作者：
Morgan, Michael M.
影响因子：
7.6
作者：
Leitl, Michael D.;Onvani, Sara;Negus, Stevens
通讯作者：
Negus, Stevens
影响因子：
3.6
作者：
Andrews, N.;Legg, E.;Rice, A. S. C.
通讯作者：
Rice, A. S. C.
影响因子：
1.6
作者：
Leitl MD;Negus SS
通讯作者：
Negus SS
影响因子：
3.4
作者：
Cone K;Lanpher J;Kinens A;Richard P;Couture S;Brackin R;Payne E;Harrington K;Rice KC;Stevenson GW
通讯作者：
Stevenson GW