Effect of catgut implantation at acupoints for the treatment of allergic rhinitis: a randomized, sham-controlled trial.
Effect of catgut implantation at acupoints for the treatment of allergic rhinitis: a randomized, sham-controlled trial.
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穴位埋线治疗过敏性鼻炎的随机、假对照试验
DOI：
10.1186/s12906-016-1400-x
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发表时间：
2016-11-10
影响因子：
--
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Li X;Liu Y;Zhang Q;Xiang N;He M;Zhong J;Chen Q;Wang X
穴位埋线治疗变应性鼻炎（ICD-10编码J30.4）的疗效和安全性仍存在争议。在这里，我们使用了假羊肠线植入组，以确定是否羊肠线植入穴位是一种有效和安全的治疗过敏性rhinitis.MethodsA随机双盲临床试验，平行组进行。入组前进行皮肤点刺试验（SPT）确诊。受试者接受两次穴位主动或假埋线治疗（每两周一次），随访期为8周。采用视觉模拟评分法（VAS）和鼻结膜炎生活质量问卷（RQLQ）评估变应性鼻炎的严重程度。抗过敏药物的使用被用作次要指标。不良事件的发生率也被记录和analysed.ResultsAn改善的VAS和RQLQ评分，观察在两个积极的和假对照组治疗后4周和8周的自我对照分析。治疗组和假手术组之间的比较显示，直到2周治疗方案后8周，治疗组和假手术组之间没有显著差异（t=-2.424，P = 0.017）。然而，治疗结束4周后，两组的RQLQ评分存在显著差异（t=-2.045，P = 0.05），这种差异一直持续到8周随访结束（t=-2.246，P = 0.033）。在整个治疗方案中，没有参与者服用任何缓解药物，也没有严重的不良事件发生。ConclusionOur findings suggest that catgut implantation at acupuncture is a effective and safe method for symptomatic treatment of allergic rhinitis. 12002191 (Date注册日期：2012-05-09）
BackgroundThe effect and safety of catgut implantation at acupoints o treat allergic rhinitis (ICD-10 code J30.4) remain controversial. Here, we used a sham catgut implantation group to determine whether catgut implantation at acupoints is an effective and safe treatment for allergic rhinitis.MethodsA randomized double-blind clinical trial, with parallel groups was conducted. Skin prick and puncture test (SPT) was performed to confirm the diagnosis before enrollment. The participants received two sessions of treatments of active or sham catgut implantation at acupoints (once every two weeks) with a follow-up phase of 8 weeks. The visual analogue scale (VAS) and Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) were used to determine the severity of allergic rhinitis. The use of anti-allergic medication was used as a secondary indicator. The incidence of adverse events was also recorded and analyzed.ResultsAn improvement of the VAS and RQLQ scores was observed in both the active and sham-controlled group sat four and eight weeks after the treatment in the self-control analysis. Comparison revealed no significant difference between the treatment and sham-controlled groups until 8 weeks after the 2-week treatment regimen (t= −2.424,P= 0.017). However, the RQLQ scores significantly differed between the two groups after 4 weeks of treatment completion (t= −2.045,P= 0.05) and this difference lasted until the end of 8-week follow-up (t= −2.246,P= 0.033). Throughout the treatment regimen, none of the participants took any relief medication, and no severe adverse events occurred.ConclusionOur findings suggest that catgut implantation at acupoints is an effective and safe method for symptomatic treatment of allergic rhinitis.Trial registrationChinese Clinical Trial Registry ChiCTR-TRC- 12002191 (Date of Registration: 2012-05-09)
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影响因子：
5.7
作者：
Xue, CCL;English, R;Li, CG
通讯作者：
Li, CG
影响因子：
168.9
作者：
Streitberger, K;Kleinhenz, J
通讯作者：
Kleinhenz, J
影响因子：
6.1
作者：
JUNIPER, EF;GUYATT, GH
通讯作者：
GUYATT, GH
影响因子：
--
作者：
Ortiz M;Witt CM;Binting S;Helmreich C;Hummelsberger J;Pfab F;Wullinger M;Irnich D;Linde K;Niggemann B;Willich SN;Brinkhaus B
通讯作者：
Brinkhaus B
影响因子：
6.1
作者：
Roberts, G;Mylonopoulou, M;Lack, G
通讯作者：
Lack, G