Mechanisms of Reaginic Hypersensitivity and IgE Antibody Response
Mechanisms of Reaginic Hypersensitivity and IgE Antibody Response
复制标题
反应性超敏反应和 IgE 抗体反应的机制
DOI：
10.1111/j.1600-065x.1978.tb01462.x
复制
发表时间：
1978
影响因子：
8.7
通讯作者：
T. Ishizaka
中科院分区：
文献类型：
--
作者：
Kimishige Ishizaka And;T. Ishizaka
免疫球蛋白E是我们在研究花粉热患者血清中的反应素抗体时发现的，并被鉴定为反应素抗体活性的载体（Ishizaka et al. 1966 a，B，Ishizaka & Ishizaka 1967）。将豚草敏感个体的纯化IgE制剂注射到正常皮肤中，导致皮肤部位对PrausnitzKiistner（P-K）反应的致敏，并且通过抗IgE去除特应性患者血清中的IgE抗体伴随着致敏活性的丧失。随后的研究表明，不仅在豚草系统中，而且在其他过敏原反应素系统中也发现了反应素活性与IgE的关联。免疫球蛋白的抗原分析（Ishizaka et al. 1967 d）和作为E骨髓瘤蛋白的模拟骨髓瘤蛋白ND的鉴定（Johansson & Bennich 1967，Bennich et al. 1968）确定IgE代表独特的免疫球蛋白类别。从那时起，我们实验室的努力一直集中在研究反应素超敏反应的免疫学机制。将反应素抗体鉴定为IgE为解决这一问题提供了免疫化学方法。在过去的几年中，我们也研究了IgE抗体反应中的细胞事件。虽然这两个主题是无关的，我们将总结我们的研究结果的免疫学机制的IgG介导的反应，其次是IgE抗体反应的机制。
Immunoglobulin E was found when we were studying reaginic antibody in the serum of hay fever patients and was identified as a carrier of reaginic antibody activity (Ishizaka et al. 1966a, b, Ishizaka & Ishizaka 1967). An injection of purified IgE preparation from ragweed sensitive individuals into normal skin resulted in the sensitization of the skin site for the PrausnitzKiistner (P-K) reaction, and the removal of IgE antibody in the serum of atopic patients by anti-IgE was accompanied by loss of sensitizing activity. Subsequent studies have shown that association of reaginic activity with IgE was found not only in the ragweed system but also in the other allergenreagin systems. Antigenic analysis of the immunoglobulin (Ishizaka et al. 1967d) and identification of a imique myeloma protein ND as an E myeloma protein (Johansson & Bennich 1967, Bennich et al. 1968) established that IgE represents a unique immunoglobulin class. Since then, effort in our laboratory has been focused to study immtinological mechanisms of reaginic hypersensitivity reactions. Identification of reaginic antibody as IgE provided immunochemical approaches to solve the problems. In the past several years, we have also studied cellular events in the IgE antibody response. Although the two subjects are unrelated, we shall summarize our findings on the immunological mechanisms of IgB-mediated reactions first, followed by mechanisms of IgE antibody response.
影响因子：
2
作者：
Liu, Yanming;Yue, Haiyan;Li, Furong
通讯作者：
Li, Furong