Severe Fatigue and Memory Impairment Are Associated with Lower Serum Level of Anti-SARS-CoV-2 Antibodies in Patients with Post-COVID Symptoms.
Severe Fatigue and Memory Impairment Are Associated with Lower Serum Level of Anti-SARS-CoV-2 Antibodies in Patients with Post-COVID Symptoms.
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DOI：
10.3390/jcm10194337
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发表时间：
2021-09-23
影响因子：
3.9
通讯作者：
Csecsei P
中科院分区：
文献类型：
--
作者：
Molnar T;Varnai R;Schranz D;Zavori L;Peterfi Z;Sipos D;Tőkés-Füzesi M;Illes Z;Buki A;Csecsei P
背景：新冠肺炎后表现被定义为发病后 4 周以上的持续症状或长期并发症。疲劳和记忆障碍是新冠病毒感染后的常见症状。我们的目的是探讨新冠肺炎后疲劳的时间线和严重程度与抗 SARS-CoV-2 抗体之间的关联。方法：使用 Chalder 疲劳量表 (CFQ-11) 和视觉模拟量表对总共 101 名新冠肺炎后受试者的疲劳和记忆障碍进行评估。使用CFQ-11生成的双峰评分系统，得分≥4被定义为严重疲劳。在两个时间点检查血清抗 SARS-CoV-2 尖峰（抗 S-Ig）和核衣壳（抗 NC-Ig）抗体：症状出现后 4-12 周以及 12 周后。结果：在 4-12 周 (p = 0.006) 和超过 12 周 (p = 0.016) 时，非严重疲劳患者的血清抗 S-Ig 水平显着高于严重疲劳患者。在两个时间点，非严重疲劳患者的抗 NC-Ig 血清水平仍然很高。相比之下，无论经过多长时间，严重疲劳病例中抗 NC-Ig 均显着下降（4-12 周：p = 0.024；超过 12 周：p = 0.005）。记忆障碍的发生率与较低的抗 S-Ig 水平显着相关（-0.359，p < 0.001）。结论：SARS-CoV-2抗体反映的全身免疫反应与新冠病毒后疲劳的严重程度密切相关。
Background: Post-COVID manifestation is defined as persistent symptoms or long-term complications beyond 4 weeks from disease onset. Fatigue and memory impairment are common post-COVID symptoms. We aimed to explore associations between the timeline and severity of post-COVID fatigue and anti-SARS-CoV-2 antibodies. Methods: Fatigue and memory impairment were assessed in a total of 101 post-COVID subjects using the Chalder fatigue scale (CFQ-11) and a visual analogue scale. Using the bimodal scoring system generated from CFQ-11, a score ≥4 was defined as severe fatigue. Serum anti-SARS-CoV-2 spike (anti-S-Ig) and nucleocapsid (anti-NC-Ig) antibodies were examined at two time points: 4–12 weeks after onset of symptoms, and beyond 12 weeks. Results: The serum level of anti-S-Ig was significantly higher in patients with non-severe fatigue compared to those with severe fatigue at 4–12 weeks (p = 0.006) and beyond 12 weeks (p = 0.016). The serum level of anti-NC-Ig remained high in patients with non-severe fatigue at both time points. In contrast, anti-NC-Ig decreased significantly in severe fatigue cases regardless of the elapsed time (4–12 weeks: p = 0.024; beyond 12 weeks: p = 0.005). The incidence of memory impairment was significantly correlated with lower anti-S-Ig levels (−0.359, p < 0.001). Conclusion: The systemic immune response reflected by antibodies to SARS-CoV-2 is strongly correlated with the severity of post-COVID fatigue.
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影响因子：
7.4
作者：
Raijmakers RPH;Roerink ME;Jansen AFM;Keijmel SP;Gacesa R;Li Y;Joosten LAB;van der Meer JWM;Netea MG;Bleeker-Rovers CP;Xu CJ
通讯作者：
Xu CJ
DOI：
10.1016/j.jinf.2021.01.004
发表时间：
2021-03
期刊：
The Journal of infection
影响因子：
--
作者：
Moreno-Pérez O;Merino E;Leon-Ramirez JM;Andres M;Ramos JM;Arenas-Jiménez J;Asensio S;Sanchez R;Ruiz-Torregrosa P;Galan I;Scholz A;Amo A;González-delaAleja P;Boix V;Gil J;COVID19-ALC research group
通讯作者：
COVID19-ALC research group
影响因子：
9.3
作者：
Gardoni F;Boraso M;Zianni E;Corsini E;Galli CL;Cattabeni F;Marinovich M;Di Luca M;Viviani B
通讯作者：
Viviani B
影响因子：
6.4
作者：
Guthmiller JJ;Stovicek O;Wang J;Changrob S;Li L;Halfmann P;Zheng NY;Utset H;Stamper CT;Dugan HL;Miller WD;Huang M;Dai YN;Nelson CA;Hall PD;Jansen M;Shanmugarajah K;Donington JS;Krammer F;Fremont DH;Joachimiak A;Kawaoka Y;Tesic V;Madariaga ML;Wilson PC
通讯作者：
Wilson PC
影响因子：
8
作者：
McAndrews, Kathleen M.;Dowlatshahi, Dara P.;Kalluri, Raghu
通讯作者：
Kalluri, Raghu