Post-acute COVID-19 syndrome. Incidence and risk factors: A Mediterranean cohort study.
Post-acute COVID-19 syndrome. Incidence and risk factors: A Mediterranean cohort study.
复制标题
DOI：
10.1016/j.jinf.2021.01.004
复制
发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
COVID19-ALC research group
中科院分区：
文献类型：
--
作者：
Moreno-Pérez O;Merino E;Leon-Ramirez JM;Andres M;Ramos JM;Arenas-Jiménez J;Asensio S;Sanchez R;Ruiz-Torregrosa P;Galan I;Scholz A;Amo A;González-delaAleja P;Boix V;Gil J;COVID19-ALC research group
本研究旨在分析急性COVID-19后综合征（PCS）及其组分的发生率，并评估急性感染期相关危险因素。一项前瞻性队列研究，研究对象为经PCR或后续血清转化证实的COVID-19（2020年2月27日至4月29日）痊愈的成年患者，并在疾病发作后10-14周进行系统评估。PCS定义为持续存在至少一种临床相关症状，或肺量测定或胸部放射学异常。结果预测因素采用多元Logistic回归分析（OR; 95%CI）。在疾病发作后77天（IQR 72-85），对277例从轻度（34.3%）或重度（65.7%）SARS-CoV-2感染中恢复的患者进行了评估。在141例患者中检测到PCS（50.9%; 95%CI 45.0-56.7%）。症状大多轻微。25/269（9.3%）例患者的肺量测定出现变化，而51/277（18.9%）例患者的X线片出现变化。没有基线临床特征表现为PCS发展的独立预测因素。在一半的COVID-19幸存者中检测到急性COVID-19综合征。放射学和肺功能测定的变化是轻微的，在不到25%的患者中观察到。没有基线临床特征表现为急性后COVID-19综合征发展的独立预测因素。
This study aims to analyze the incidence of Post-acute COVID-19 syndrome (PCS) and its components, and to evaluate the acute infection phase associated risk factors. A prospective cohort study of adult patients who had recovered from COVID-19 (27th February to 29th April 2020) confirmed by PCR or subsequent seroconversion, with a systematic assessment 10–14 weeks after disease onset. PCS was defined as the persistence of at least one clinically relevant symptom, or abnormalities in spirometry or chest radiology. Outcome predictors were analyzed by multiple logistic regression (OR; 95%CI). Two hundred seventy seven patients recovered from mild (34.3%) or severe (65.7%) forms of SARS-CoV-2 infection were evaluated 77 days (IQR 72–85) after disease onset. PCS was detected in 141 patients (50.9%; 95%CI 45.0–56.7%). Symptoms were mostly mild. Alterations in spirometry were noted in 25/269 (9.3%), while in radiographs in 51/277 (18.9%). No baseline clinical features behaved as independent predictors of PCS development. A Post-acute COVID-19 syndrome was detected in a half of COVID19 survivors. Radiological and spirometric changes were mild and observed in less than 25% of patients. No baseline clinical features behaved as independent predictors of Post-acute COVID-19 syndrome development.
登录
查看更多内容
影响因子：
15.1
作者：
Zhao, Yu-miao;Shang, Yao-min;Xu, Ai-guo
通讯作者：
Xu, Ai-guo
影响因子：
3.7
作者：
Townsend L;Dyer AH;Jones K;Dunne J;Mooney A;Gaffney F;O'Connor L;Leavy D;O'Brien K;Dowds J;Sugrue JA;Hopkins D;Martin-Loeches I;Ni Cheallaigh C;Nadarajan P;McLaughlin AM;Bourke NM;Bergin C;O'Farrelly C;Bannan C;Conlon N
通讯作者：
Conlon N
影响因子：
5.8
作者：
Huang, Yiying;Tan, Cuiyan;Liu, Jing
通讯作者：
Liu, Jing
影响因子：
12.7
作者：
Halpin, Stephen J.;McIvor, Claire;Sivan, Manoj
通讯作者：
Sivan, Manoj
DOI：
10.1016/j.cmi.2020.09.052
发表时间：
2021-03
期刊：
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
影响因子：
--
作者：
Carvalho-Schneider C;Laurent E;Lemaignen A;Beaufils E;Bourbao-Tournois C;Laribi S;Flament T;Ferreira-Maldent N;Bruyère F;Stefic K;Gaudy-Graffin C;Grammatico-Guillon L;Bernard L
通讯作者：
Bernard L