Influence of early-life nutritional stress on songbird memory formation
Influence of early-life nutritional stress on songbird memory formation
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生命早期营养应激对鸣禽记忆形成的影响
DOI：
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
K. Buchanan
中科院分区：
文献类型：
--
作者：
B. Bell;M. Phan;Alizée Meillère;J. K. Evans;S. Leitner;D. Vicario;K. Buchanan
对于鸟类来说，声音学习能够产生有性选择的复杂歌曲、方言和歌曲副本匹配。但发育过程中的压力条件已被证明会影响歌曲的产生和复杂性，这是由神经发育的变化介导的。然而，迄今为止，还没有研究测试早期生活压力是否会影响声音学习的神经过程，与歌曲制作相反。在这里，我们假设发育压力会改变听觉记忆的形成和歌曲刺激的神经处理。我们对雄性雏鸟斑胸草雀进行了实验应激，并在两个独立的实验中，使用立即早期基因（IEG）表达或电生理反应测试了它们成年后对歌曲播放的神经反应。一旦成年，营养紧张的男性对导师歌曲播放的反应就会减弱，这可以通过尾内侧巢皮质 (NCM) 和中皮质 (CMM) 中两种 IEG（Arc 和 ZENK）表达的减少以及神经元反应的减少来证明。此外，营养紧张的男性对成年后听到的新歌的神经元记忆也受到损害。这些发现首次证明，发育条件会影响听觉记忆，从而促进声音学习。尽管这种记忆障碍对健康的影响仍有待确定，但这项研究强调了早期生活经历对认知能力的持久影响。
In birds, vocal learning enables the production of sexually selected complex songs, dialects and song copy matching. But stressful conditions during development have been shown to affect song production and complexity, mediated by changes in neural development. However, to date, no studies have tested whether early-life stress affects the neural processes underlying vocal learning, in contrast to song production. Here, we hypothesized that developmental stress alters auditory memory formation and neural processing of song stimuli. We experimentally stressed male nestling zebra finches and, in two separate experiments, tested their neural responses to song playbacks as adults, using either immediate early gene (IEG) expression or electrophysiological response. Once adult, nutritionally stressed males exhibited a reduced response to tutor song playback, as demonstrated by reduced expressions of two IEGs (Arc and ZENK) and reduced neuronal response, in both the caudomedial nidopallium (NCM) and mesopallium (CMM). Furthermore, nutritionally stressed males also showed impaired neuronal memory for novel songs heard in adulthood. These findings demonstrate, for the first time, that developmental conditions affect auditory memories that subserve vocal learning. Although the fitness consequences of such memory impairments remain to be determined, this study highlights the lasting impact early-life experiences can have on cognitive abilities.
DOI：
10.1073/pnas.89.15.6818
发表时间：
1992-08-01
影响因子：
11.1
作者：
MELLO, CV;VICARIO, DS;CLAYTON, DF
通讯作者：
CLAYTON, DF