Anti-nutritive effects of dietary tin.
Anti-nutritive effects of dietary tin.
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膳食锡的抗营养作用。
DOI：
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发表时间：
1990
影响因子：
--
通讯作者：
Jeanne I. Rader
中科院分区：
文献类型：
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作者：
Jeanne I. Rader
食品中锡的含量通常低于 4 微克/克。由于添加了锡基防腐剂和稳定剂，或者未上漆的罐头或包装中使用的锡箔中的金属被腐蚀和浸出，某些加工食品中的含量可能较高。膳食摄入量估计范围为每天约 0.2 至大于 5 毫克锡。含有大量罐装蔬菜和鱼类的饮食可以提供超过 30 毫克的锡/天。虽然从饮食中摄入锡通常被认为是无害的，但已报道锡的多种不良影响，包括对血清和骨碱性磷酸酶、乳酸脱氢酶、血红素加氧酶和 5-氨基乙酰丙酸脱水酶的影响。据报道，谷胱甘肽代谢受到干扰，并对铜、锌和铁等必需微量矿物质的代谢产生不利影响。还描述了对骨、血清和肾脏钙含量的具体影响。报道的效果因锡的化学形式、剂量以及给药途径和频率而异。回顾了锡在动物系统中的影响以及对人类志愿者的必需微量矿物质吸收和排泄的影响。还总结了最近关于膳食锡-铜相互作用以及锡对大鼠肝细胞抗氧化保护的影响的研究。
Tin is usually present in foods at levels of less than 4 micrograms/g. Higher levels may be found in some processed foods due to the addition of tin-based preservatives and stabilizers or to corrosion and leaching of the metal from unlacquered cans or from tin foils used in packaging. Estimates of dietary intake range from about 0.2 to greater than 5 mg Sn/day. Diets including a high proportion of canned vegetables and fish could supply greater than 30 mg Sn/day. Although intakes from dietary sources are generally considered to be harmless, a variety of adverse effects of tin have been reported, including effects on serum and bone alkaline phosphatase, lactic dehydrogenase, heme oxygenase, and 5-aminolevulinic acid dehydratase. Perturbations in glutathione metabolism have been reported, as have adverse effects on metabolism of essential trace minerals such as copper, zinc, and iron. Specific effects on calcium content of bone, serum, and kidney have also been described. Reported effects vary with the chemical form, dose of tin, and route and frequency of administration. Effects of tin in animal systems and on essential trace mineral absorption and excretion in human volunteers are reviewed. A summary of recent investigations on dietary tin-copper interactions and effects of tin on rat hepatocellular antioxidant protection are also presented.
比较金属对离体大鼠肝细胞细胞损伤和脂质过氧化的影响。
DOI：
10.1080/15287398109529965
发表时间：
1981
期刊：
Journal of toxicology and environmental health
影响因子：
--
作者：
Stacey,NH;Klaassen,CD
通讯作者：
Klaassen,CD