G protein pathway suppressor 2 (GPS2) acts as a tumor suppressor in liposarcoma.
G protein pathway suppressor 2 (GPS2) acts as a tumor suppressor in liposarcoma.
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DOI：
10.1007/s13277-016-5220-x
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发表时间：
2016-10
期刊：
影响因子：
--
通讯作者：
Li, Pei-Yu
中科院分区：
文献类型：
--
作者：
Huang, Xiao-Dong;Xiao, Feng-Jun;Wang, Shao-Xia;Yin, Rong-Hua;Lu, Can-Rong;Li, Qing-Fang;Liu, Na;Zhang, Ying;Wang, Li-Sheng;Li, Pei-Yu
脂肪肉瘤（LPS）是最常见的软组织肉瘤类型，占所有成人肉瘤的20%.然而，这种恶性肿瘤的分子发病机制仍然知之甚少。在这里，我们发现GPS 2表达在LPS中下调，并且与这种疾病的预后相关。体外研究表明，GPS 2基因的敲低导致LPS细胞系SW 872的增殖和迁移增强，而细胞死亡没有显著影响。总之，我们的研究结果表明，GPS 2可能作为一个肿瘤抑制LPS和作为一个潜在的预后标志物，这种疾病。
Liposarcoma(LPS) is the most common type of soft tissue sarcoma accounting for 20 % of all adult sarcomas. However, the molecular pathogenesis of this malignancy is still poorly understood. Here, we showed that GPS2 expression was downregulated in LPS and correlated with the prognosis of this disease. In vitro study showed that knockdown of GPS2 resulted in enhanced proliferation and migration of LPS cell line SW872, without significant influence of cell death. Conclusively, our results suggest that GPS2 may act as a tumor suppressor in LPS and serve as a potential prognosis marker for this disease.
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影响因子：
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