A 5-year longitudinal study of schistosomiasis transmission in Shian village, the Anning River Valley, Sichuan Province, the Peoples' Republic of China.
A 5-year longitudinal study of schistosomiasis transmission in Shian village, the Anning River Valley, Sichuan Province, the Peoples' Republic of China.
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一项为期5年的纵向研究，对中华民国四川省安宁河谷的Shian Village的血吸虫病传播。
DOI：
10.1186/1756-3305-4-43
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发表时间：
2011-03-24
影响因子：
3.2
通讯作者：
McManus DP
中科院分区：
文献类型：
--
作者：
Zhu R;Gray DJ;Thrift AP;Williams GM;Zhang Y;Qiu DC;Zheng F;Li YS;Guo J;Zhu HQ;Wu WP;Li RS;McManus DP
日本血吸虫是中华人民共和国（PRC）的一个主要公共卫生问题，有超过100万人感染，另有5000万人生活在感染风险地区。根据生态、环境、人群遗传和分子等因素，中国血吸虫病传播可分为四种离散的生态系统或传播模式。预计三峡大坝将对中国血吸虫病的传播产生影响，不同传播方式的影响程度不同。2002 - 2006年，我们在湖南、江西、湖北、安徽和四川5省（区）的TGD以上和以下哨点村进行了纵向监测，以确定TGD建设期间是否对血吸虫病传播有任何影响。在这里，我们提出了一个位于四川省大坝以上的疟疾流行村的结果。基线结果显示人类S。日本血吸虫感染率为42.0%（95%CI：36.6-47.5）。随访结果显示，S. 2006年，石安县选定人群的日本血吸虫感染率从2003年的46%下降到2006年的11.3%，下降了四分之三。一个显着的（P < 0.01）下降趋势也明显在每年调整（水接触）的比值比。在4年的随访中，S.牛的日本血吸虫感染从第一年的11.8%下降到随访的最后一年的零。在石安村观察到的人（75%）和牛（100%）发病率的大幅下降可能归因于每年对阳性的人和牛进行PZQ治疗;如在中国其他地区的药物（PZQ）干预研究中所见。如果由于TGD而发生了病毒传播的增加，则与此处观察到的给药诱导的下降相比，其大小可以忽略不计。因此，在研究期间，TGD的建设对石安村的血吸虫病传播几乎没有影响。此外，与四川先前的报告淡化动物在人类传播艾滋病中的作用相反，牛可能确实发挥了作用。
Schistosoma japonicum is a major public health concern in the Peoples' Republic of China (PRC), with over one million people infected and another 50 million living in areas at risk of infection. Based on ecological, environmental, population genetic and molecular factors, schistosomiasis transmission in PRC can be categorised into four discrete ecosystems or transmission modes. It is predicted that the Three Gorges Dam (TGD) will impact upon the transmission of schistosomiasis in the PRC, with varying degree across the four transmission modes. We undertook longitudinal surveillance from 2002 to 2006 in sentinel villages both above and below the TGD across five provinces (Hunan, Jiangxi, Hubei, Anhui and Sichuan) to determine whether there was any impact of the TGD on schistosomiasis transmission during its construction. Here we present the results from a schistosomiasis-endemic village located above the dam in Sichuan Province. Baseline results showed a human S. japonicum prevalence of 42.0% (95% CI: 36.6-47.5). At follow-up, results showed that the incidence of S. japonicum infection in the selected human cohort in Shian decreased by three quarters from 46% in 2003 to 11.3% in 2006. A significant (P < 0.01) downward trend was also evident in the yearly adjusted (for water contact) odds ratios. Over the four years of follow-up, the incidence of S. japonicum infection in bovines declined from 11.8% in the first year to zero in the final year of follow-up. The substantial decrease in human (75%) and bovine (100%) incidence observed in Shian village can probably be attributed to the annual human and bovine PZQ treatment of positives; as seen in drug (PZQ) intervention studies in other parts of PRC. If an increase in schistosome transmission had occurred as a result of the TGD, it would be of negligible size compared to the treatment induced decline seen here. It appears therefore that the construction of the TGD had virtually no impact on schistosomiasis transmission in Shian village over the period of study. Furthermore, contrary to previous reports from Sichuan downplaying the role of animals in human schistosome transmission, bovines may indeed play a role.
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影响因子：
2.5
作者：
Seto, Edmund Y. W.;Wu, Weiping;Davis, George M.
通讯作者：
Davis, George M.
影响因子：
1.3
作者：
Davis, George M.;Wu, Wei Ping;Guo, Jia-Gang
通讯作者：
Guo, Jia-Gang
影响因子：
3.3
作者：
Liang, YS;Dai, JR;Coles, GC
通讯作者：
Coles, GC
影响因子：
2.4
作者：
Hubbard, A;Liang, S;Spear, RC
通讯作者：
Spear, RC
影响因子：
56.3
作者：
Gray, Darren J.;McManus, Donald P.;Ross, Allen G.
通讯作者：
Ross, Allen G.