Neuropeptide Y in Alcohol Addiction and Affective Disorders.
Neuropeptide Y in Alcohol Addiction and Affective Disorders.
复制标题
DOI：
10.3389/fendo.2017.00178
复制
发表时间：
2017
影响因子：
5.2
通讯作者：
Mathé AA
中科院分区：
文献类型：
--
作者：
Thorsell A;Mathé AA
神经肽Y(NPY)是一种在整个进化过程中高度保守的神经肽，在中枢神经系统(CNS)以及肠道和心血管系统等外周组织中都存在高水平。该肽通过多种受体亚型发挥作用，均属于G蛋白偶联受体超家族。在这些亚型中，Y1和Y2的特征最彻底，其次是Y5亚型。NPY及其受体已被证明在情感障碍、药物/酒精使用障碍和能量平衡等事件的中枢调节中具有重要作用。此外，在中枢神经系统内，NPY还影响睡眠调节和昼夜节律、记忆功能、组织生长和可塑性。神经肽Y在情绪和焦虑症以及酒精使用障碍的病因学和病理生理学中的潜在作用已被广泛研究。早期的迹象表明NPY参与了对压力的急性反应，后来又有数据表明，在慢性或重复暴露于不良事件期间，中枢神经系统内的变化起到了作用，这促使了人们对NPY的关注。NPY的这些功能，除了对疾病状态的调节外，还表明通过受体激动剂/拮抗剂调节NPY系统的活性可能是情感性障碍和酒精使用障碍的一种可能的治疗机制。在这篇综述中，我们概述了NPY系统与焦虑和压力、急性和慢性相关的研究结果；此外，我们还讨论了创伤后应激障碍和部分抑郁。此外，我们还总结了有关酒精使用障碍和相关行为的研究结果。最后，我们简要地谈到可能对NPY的功能和调控具有重要意义的遗传和表观遗传机制。总之，我们认为，通过针对不同受体亚型的配体来调节中枢神经系统内的NPY能活性，可能是治疗情感性障碍和酒精使用障碍的有吸引力的靶点。
Neuropeptide Y (NPY), a neuropeptide highly conserved throughout evolution, is present at high levels in the central nervous system (CNS), as well as in peripheral tissues such as the gut and cardiovascular system. The peptide exerts its effects via multiple receptor subtypes, all belonging to the G-protein-coupled receptor superfamily. Of these subtypes, the Y1 and the Y2 are the most thoroughly characterized, followed by the Y5 subtype. NPY and its receptors have been shown to be of importance in central regulation of events underlying, for example, affective disorders, drug/alcohol use disorders, and energy homeostasis. Furthermore, within the CNS, NPY also affects sleep regulation and circadian rhythm, memory function, tissue growth, and plasticity. The potential roles of NPY in the etiology and pathophysiology of mood and anxiety disorders, as well as alcohol use disorders, have been extensively studied. This focus was prompted by early indications for an involvement of NPY in acute responses to stress, and, later, also data pointing to a role in alterations within the CNS during chronic, or repeated, exposure to adverse events. These functions of NPY, in addition to the peptide’s regulation of disease states, suggest that modulation of the activity of the NPY system via receptor agonists/antagonists may be a putative treatment mechanism in affective disorders as well as alcohol use disorders. In this review, we present an overview of findings with regard to the NPY system in relation to anxiety and stress, acute as well as chronic; furthermore we discuss post-traumatic stress disorder and, in part depression. In addition, we summarize findings on alcohol use disorders and related behaviors. Finally, we briefly touch upon genetic as well as epigenetic mechanisms that may be of importance for NPY function and regulation. In conclusion, we suggest that modulation of NPY-ergic activity within the CNS, via ligands aimed at different receptor subtypes, may be attractive targets for treatment development for affective disorders, as well as for alcohol use disorders.
登录
查看更多内容
影响因子：
10.6
作者：
Coccaro, Emil F.;Lee, Royce;Mathe, Aleksander A.
通讯作者：
Mathe, Aleksander A.
影响因子：
3.6
作者：
Cippitelli, Andrea;Damadzic, Ruslan;Singley, Erick;Thorsell, Annika;Ciccocioppo, Roberto;Eskay, Robert L.;Heilig, Markus
通讯作者：
Heilig, Markus
影响因子：
2.5
作者：
Bice, P;Foroud, T;Carr, LG
通讯作者：
Carr, LG
DOI：
10.1097/00000374-199806000-00017
发表时间：
1998-06-01
影响因子：
3.2
作者：
Carr, LG;Foroud, T;Li, TK
通讯作者：
Li, TK
影响因子：
3.4
作者：
Britton, KT;Southerland, S;Koob, G
通讯作者：
Koob, G