A modern day perspective on smoking in peripheral artery disease.
A modern day perspective on smoking in peripheral artery disease.
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DOI：
10.3389/fcvm.2023.1154708
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发表时间：
2023
影响因子：
3.6
通讯作者：
Hamburg, Naomi M.
中科院分区：
文献类型：
--
作者：
Behrooz, Leili;Abumoawad, Abdelrhman;Rizvi, Syed Husain M.;Hamburg, Naomi M.
关键词：
外周动脉疾病（PAD）与心血管发病率和死亡率、功能状态差和生活质量降低的风险增加相关。吸烟是PAD的主要可预防风险因素，与疾病进展风险较高、术后结局较差和医疗保健利用增加密切相关。PAD中动脉粥样硬化病变导致的动脉狭窄导致肢体灌注减少，并最终导致动脉阻塞和肢体缺血。内皮细胞功能障碍、氧化应激、炎症和动脉硬化是动脉粥样硬化形成过程中的关键事件。在这篇综述中，我们讨论了PAD患者戒烟的益处以及包括药物治疗在内的戒烟方法的使用。鉴于戒烟干预措施仍未得到充分利用，我们强调将戒烟治疗作为PAD患者医疗管理的一部分的重要性。减少烟草制品使用和支持戒烟的监管方法有可能减轻PAD的负担。
Peripheral artery disease (PAD) is associated with increased risk of cardiovascular morbidity and mortality, poor functional status, and lower quality of life. Cigarette smoking is a major preventable risk factor for PAD and is strongly associated with a higher risk of disease progression, worse post-procedural outcomes, and increased healthcare utilization. The arterial narrowing due to atherosclerotic lesions in PAD leads to decreased perfusion to the limbs and can ultimately cause arterial obstruction and limb ischemia. Endothelial cell dysfunction, oxidative stress, inflammation, and arterial stiffness are among the key events during the development of atherogenesis. In this review, we discuss the benefits of smoking cessation among patients with PAD and the use of smoking cessation methods including pharmacological treatment. Given that smoking cessation interventions remain underutilized, we highlight the importance of incorporating smoking cessation treatments as part of the medical management of patients with PAD. Regulatory approaches to reduce the uptake of tobacco product use and support smoking cessation have the potential to reduce the burden of PAD.
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影响因子：
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