Toll-Like Receptor Signaling and Its Role in Cell-Mediated Immunity.
Toll-Like Receptor Signaling and Its Role in Cell-Mediated Immunity.
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DOI：
10.3389/fimmu.2022.812774
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发表时间：
2022
影响因子：
7.3
通讯作者：
Wang RF
中科院分区：
文献类型：
--
作者：
Duan T;Du Y;Xing C;Wang HY;Wang RF
先天免疫是抵御入侵病原体的第一道防御系统。Toll样受体是一种定义明确的模式识别受体，负责病原体识别和诱导先天免疫反应。自发现以来，TLRs填补了天然免疫细胞最初识别病原体和激活获得性免疫反应之间的空白，从而彻底改变了免疫学领域。TLRs通过调节抗原提呈细胞和关键细胞因子的激活，将先天免疫与获得性免疫联系起来。此外，最近的研究还表明，TLR信号可以在不同的生理条件下直接调节T细胞的激活、生长、分化、发育和功能。本文综述了TLR信号通路及其调节因子，并讨论了TLR信号如何直接和间接地调节细胞免疫。此外，我们还讨论了TLR信号在宿主抵御传染病、自身免疫性疾病和癌症中的重要作用。
Innate immunity is the first defense system against invading pathogens. Toll-like receptors (TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition and induction of innate immune responses. Since their discovery, TLRs have revolutionized the field of immunology by filling the gap between the initial recognition of pathogens by innate immune cells and the activation of the adaptive immune response. TLRs critically link innate immunity to adaptive immunity by regulating the activation of antigen-presenting cells and key cytokines. Furthermore, recent studies also have shown that TLR signaling can directly regulate the T cell activation, growth, differentiation, development, and function under diverse physiological conditions. This review provides an overview of TLR signaling pathways and their regulators and discusses how TLR signaling, directly and indirectly, regulates cell-mediated immunity. In addition, we also discuss how TLR signaling is critically important in the host’s defense against infectious diseases, autoimmune diseases, and cancer.
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