Advances in the role of m(6)A RNA modification in cancer metabolic reprogramming.
Advances in the role of m(6)A RNA modification in cancer metabolic reprogramming.
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DOI：
10.1186/s13578-020-00479-z
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发表时间：
2020
影响因子：
7.5
通讯作者：
Han Q
中科院分区：
文献类型：
--
作者：
Han X;Wang L;Han Q
N6-甲基腺苷（m6 A）修饰是真核生物mRNA最常见的内部修饰，广泛参与许多细胞过程，如RNA转录、剪接、核转运、降解和翻译。m6 A已被证明在各种癌症的发生和发展中起重要作用。癌细胞代谢程序的改变促进了它们的细胞自主增殖和存活，从而成为癌症不可或缺的标志。越来越多的证据表明，这种表观遗传修饰通过直接调节代谢基因的表达或调节代谢相关的信号通路对癌症代谢网络产生广泛的影响。本文就m6 A的调控机制、生物学功能及其在肿瘤代谢重编程中的作用作一综述。
N6-methyladenosine (m6A) modification is the most common internal modification of eukaryotic mRNA and is widely involved in many cellular processes, such as RNA transcription, splicing, nuclear transport, degradation, and translation. m6A has been shown to plays important roles in the initiation and progression of various cancers. The altered metabolic programming of cancer cells promotes their cell-autonomous proliferation and survival, leading to an indispensable hallmark of cancers. Accumulating evidence has demonstrated that this epigenetic modification exerts extensive effects on the cancer metabolic network by either directly regulating the expression of metabolic genes or modulating metabolism-associated signaling pathways. In this review, we summarized the regulatory mechanisms and biological functions of m6A and its role in cancer metabolic reprogramming.
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YTHDF2 通过直接招募 CCR4-NOT 去腺苷酶复合物来破坏含有 m(6)A 的 RNA 的稳定性。
影响因子：
16.6
作者：
Du, Hao;Zhao, Ya;He, Jinqiu;Zhang, Yao;Xi, Hairui;Liu, Mofang;Ma, Jinbiao;Wu, Ligang
通讯作者：
Wu, Ligang
影响因子：
30.8
作者：
通讯作者：
--
影响因子：
50.3
作者：
Chae YC;Vaira V;Caino MC;Tang HY;Seo JH;Kossenkov AV;Ottobrini L;Martelli C;Lucignani G;Bertolini I;Locatelli M;Bryant KG;Ghosh JC;Lisanti S;Ku B;Bosari S;Languino LR;Speicher DW;Altieri DC
通讯作者：
Altieri DC
影响因子：
16.6
作者：
Chen, Kai;Lu, Zhike;Wang, Xiao;Fu, Ye;Luo, Guan-Zheng;Liu, Nian;Han, Dali;Dominissini, Dan;Dai, Qing;Pan, Tao;He, Chuan
通讯作者：
He, Chuan
DOI：
10.1261/rna.065219.117
发表时间：
2018-03
期刊：
RNA (New York, N.Y.)
影响因子：
--
作者：
Darnell RB;Ke S;Darnell JE Jr
通讯作者：
Darnell JE Jr