Analysis of the T‐cell micro‐environment in Epstein–Barr virus‐related post‐transplantation B lymphoproliferative disease
Analysis of the T‐cell micro‐environment in Epstein–Barr virus‐related post‐transplantation B lymphoproliferative disease
复制标题
EB病毒相关移植后B淋巴细胞增殖性疾病的T细胞微环境分析
作者：
S. Perera;J. Thomas;M. Burke;D. Crawford
EB病毒（EBV）移植后B淋巴组织增生性疾病（BLPD）在免疫功能低下的同种异体移植宿主中，在免疫抑制剂撤药和EBV特异性细胞毒性T细胞（CTL）活性恢复后可能会消退。BLPD微环境中形态正常的T细胞的存在可能会影响体内肿瘤的行为。在这项免疫病理学研究中，T细胞和其他免疫调节细胞的表型和数量进行了研究，在7个原发性和4个复发性BLPD活检从9个实体器官移植受者。发现具有病毒性淋巴结病或多态性淋巴瘤外观的BLPD含有大量T细胞群，主要为记忆/辅助（TCRα/β+、CD 3+、CD 4+、CD 45 RO+）型。细胞毒性（TCRα/β+、CD 3、CD 8+、Tia-1+）T细胞在所有样本中均显著较低。CD 28和CD 25的低表达表明，这些肿瘤中功能性和持续T细胞活化的次要信号可能缺乏。在T细胞浸润程度和临床结局之间没有发现密切相关性，尽管在治疗后显示长期临床缓解的三种BLPD肿瘤中检测到明显较高数量的CD 8 + T细胞。虽然在未经治疗的BLPD中可能存在一定水平的EBV特异性T细胞功能，但本研究的总体结果表明，T细胞浸润的性质可能反映了对免疫抑制治疗的反应，而不是对EBV感染本身的反应。需要研究在治疗后发生消退的BLPD中产生局部EBV特异性T细胞应答的可能性。© 1998 John Wiley & Sons，Ltd.
Epstein–Barr virus (EBV) post‐transplantation B lymphoproliferative disease (BLPD) may undergo regression after immunosuppression withdrawal and restoration of EBV‐specific cytotoxic T‐cell (CTL) activity in the immunocompromised allografted host. The presence of morphologically normal T cells in the BLPD micro‐environment may influence tumour behaviour in vivo. In this immunopathological study, the phenotype and the number of T cells and other immunoregulatory cells have been investigated in seven primary and four recurrent BLPD biopsies from nine solid organ transplant recipients. BLPD with either viral lymphadenopathic or polymorphic lymphoma appearances was found to contain sizeable T‐cell populations, mainly of memory/helper (TCRα/β+, CD3+, CD4+, CD45RO+) type. Cytotoxic (TCRα/β+, CD3, CD8+, Tia‐1+) T cells were strikingly low in all samples. Low CD28 and CD25 expression suggested that secondary signals for functional and sustained T‐cell activation may be deficient in these tumours. No close correlation was found between the degree of T‐cell infiltration and clinical outcome, although appreciably higher numbers of CD8+ T cells were detected in three BLPD tumours showing prolonged clinical remission after treatment. While some level of EBV‐specific T‐cell function may be present in untreated BLPD, the overall findings of this study suggest that the nature of T‐cell infiltrates may reflect a response to immunosuppressive therapy rather than to EBV infection per se. The possibility that a local EBV‐specific T‐cell response is generated in BLPD undergoing regression after treatment needs to be investigated. © 1998 John Wiley & Sons, Ltd.
急性传染性单核细胞增多症期间 T 细胞介导的细胞毒性的表征。
DOI：
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发表时间：
1989
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Tomkinson,BE;Maziarz,R;Sullivan,JL
通讯作者：
Sullivan,JL
影响因子：
56.9
作者：
FRASER, JD;IRVING, BA;WEISS, A
通讯作者：
WEISS, A
影响因子：
158.5
作者：
PAPADOPOULOS, EB;LADANYI, M;OREILLY, RJ
通讯作者：
OREILLY, RJ