Effects of the Lipoprotein Lipase Activator NO-1886 as a Suppressor Agent of Atherosclerosis in Aorta of Mild Diabetic Rabbits
Effects of the Lipoprotein Lipase Activator NO-1886 as a Suppressor Agent of Atherosclerosis in Aorta of Mild Diabetic Rabbits
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脂蛋白脂肪酶激活剂NO-1886作为轻度糖尿病兔主动脉粥样硬化抑制剂的作用
DOI：
10.1055/s-0031-1299939
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Baotang Yang
中科院分区：
文献类型：
--
作者：
W. Yin;K. Tsutsumi;Zhonghua Yuan;Baotang Yang
合成化合物NO-1886（[4-溴-2-氰基-苯基氨基甲酰基]-苄基] -膦酸二乙酯，CAS 133208-93-2）是一种脂蛋白脂肪酶激活剂，可降低血浆甘油三酯并升高高密度脂蛋白胆固醇（HDL-C）水平。然而，NO-1886对糖尿病患者血糖水平和动脉粥样硬化的影响尚不清楚。本研究的目的是确定该化合物是否降低患有高脂肪/高蔗糖诱导的轻度糖尿病的新西兰白色兔的血糖并抑制动脉粥样硬化。高脂/高糖喂养增加血浆总胆固醇、甘油三酯和葡萄糖水平，降低HDL-C水平，导致主动脉粥样硬化。NO-1886给药20周后，家兔血浆总胆固醇、甘油三酯和葡萄糖水平降低，HDL-C水平升高。此外，NO-1886提供了对主动脉中动脉粥样硬化发展的保护。这些数据表明，NO-1886不仅改善脂质紊乱，而且降低血糖水平和抑制糖尿病兔主动脉粥样硬化。
Summary The synthetic compound NO-1886 ([4(4-bromo-2-cyano-phenylcarbamoyl)-benzyl] -phosphonic acid diethyl ester, CAS 133208-93-2) is a lipoprotein lipase activator which decreases plasma triglycerides and elevates high-density lipoprotein cholesterol (HDL-C) levels. However, the effects of NO-1886 on plasma glucose level and atherosclerosis in diabetes are not clear. The aim of this study was to ascertain whether the compound lowers plasma glucose and suppresses atherosclerosis in New Zealand White rabbits with high fat/high sucrose-induced mild diabetes. High fat/high sucrose feeding increased plasma total cholesterol, trigly ceride and glucose levels and decreased HDL-C levels resulting in atherosclerosis in the aorta. Administration of NO-1886 to the rabbits resulted in decreased plasma total cholesterol, triglyceride and glucose levels and increased HDL-C levels after 20 weeks of treatment. Furthermore, NO-1886 provided protection against the development of atherosclerosis in the aorta. These data indicate that NO-1886 not only ameliorates the lipid disorder, but also lowers plasma glucose levels and suppresses atherosclerosis in the aorta of diabetic rabbits.
肿瘤坏死因子-α的脂肪表达--在与肥胖相关的胰岛素抵抗中的直接作用
影响因子：
56.9
作者：
HOTAMISLIGIL, GS;SHARGILL, NS;SPIEGELMAN, BM
通讯作者：
SPIEGELMAN, BM
影响因子：
15.9
作者：
KERN, PA;SAGHIZADEH, M;SIMSOLO, RB
通讯作者：
SIMSOLO, RB