Development of Retinal Layers in Prenatal Human Retina.
Development of Retinal Layers in Prenatal Human Retina.
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产前人类视网膜视网膜层的发育。
DOI：
10.1016/j.ajo.2015.09.023
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发表时间：
2016-01
影响因子：
4.2
通讯作者：
Hendrickson A
中科院分区：
文献类型：
--
作者：
Hendrickson A
确定视网膜层的发育顺序，以提供有关子宫内病理事件可能影响视网膜发育的信息。定性和定量描述性研究。对从胎儿第 8 周 (Fwk) 到产后 (P) 10 周的人眼组织学采集进行了分析。沿水平子午线测量 20 只眼睛的鼻部和颞部视网膜的长度。在每个年龄确定内丛状层（IPL）和外丛状层（OPL）的位置，并测量其长度。人眼视网膜长度从胎龄 8 时的 5.19 毫米增加到妊娠中期的 20.92 毫米，再到出生后的 32.88 毫米。 IPL 在第 8 周出现在假定的中央凹，在第 12 周到达视神经的偏心处，并在第 18-21 周出现在鼻和颞外周边缘。相比之下，OPL 发展缓慢。短 OPL 首先出现在 Fwk 11 中央凹，直到妊娠中期才到达视神经的偏心率。 OPL 在 Fwk 30 时到达视网膜边缘。IPL 和 OPL 的层状发育发生在血管形成之前。在人类胎儿视网膜中，IPL 在妊娠中期到达视网膜的远周边边缘，而 OPL 在妊娠晚期到达视网膜的远周边边缘。只有非常早期的子宫内事件才会影响中央视网膜的 IPL 层状发育，但 Fwk 20 之后发生的周边视网膜事件将与外层视网膜的 OPL 层状发育重叠。
To determine the developmental sequence of retinal layers to provide information on where in utero pathologic events might affect retinal development. Qualitative and quantitative descriptive research. A histology collection of human eyes from fetal week (Fwk) 8 to postnatal (P) 10 weeks was analyzed. The length of the nasal and temporal retina was measured along the horizontal meridian in 20 eyes. The location of the inner plexiform layer (IPL) and outer plexiform layer (OPL) was identified at each age, and its length measured. The human eye retinal length increased from 5.19 mm at Fwk 8 to 20.92 mm at midgestation to 32.88 mm just after birth. The IPL appeared in the presumptive fovea at Fwk 8, reached the eccentricity of the optic nerve by Fwk 12, and was present to both nasal and temporal peripheral edges by Fwk 18–21. By contrast, the OPL developed slowly. A short OPL was first present in the Fwk 11 fovea and did not reach the eccentricity of the optic nerve until midgestation. The OPL reached the retinal edges by Fwk 30. Laminar development of both IPL and OPL occurred before vascular formation. In human fetal retina, the IPL reached the far peripheral edge of the retina by midgestation and the OPL by late gestation. Only very early in utero events could affect IPL lamination in the central retina, but events occurring after Fwk 20 in the peripheral retina would overlap OPL laminar development in outer retina.
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影响因子：
4.2
作者：
Vajzovic, Lejla;Hendrickson, Anita E.;O'Connell, Rachelle V.;Clark, Laura A.;Tran-Viet, Du;Possin, Daniel;Chiu, Stephanie J.;Farsiu, Sina;Toth, Cynthia A.
通讯作者：
Toth, Cynthia A.
影响因子：
4.2
作者：
Hendrickson, Anita;Possin, Daniel;Vajzovic, Lejla;Toth, Cynthia A.
通讯作者：
Toth, Cynthia A.
影响因子：
2.5
作者：
PROVIS, JM;VANDRIEL, D;RUSSELL, P
通讯作者：
RUSSELL, P
影响因子：
2.5
作者：
LAVAIL, MM;RAPAPORT, DH;RAKIC, P
通讯作者：
RAKIC, P
影响因子：
2.7
作者：
HENDRICKSON, A;DRUCKER, D
通讯作者：
DRUCKER, D