Antibodies to Porphyromonas gingivalis Are Increased in Patients with Severe Periodontitis, and Associate with Presence of Specific Autoantibodies and Myocardial Infarction.
Antibodies to Porphyromonas gingivalis Are Increased in Patients with Severe Periodontitis, and Associate with Presence of Specific Autoantibodies and Myocardial Infarction.
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DOI：
10.3390/jcm11041008
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发表时间：
2022-02-15
影响因子：
3.9
通讯作者：
Lundberg K
中科院分区：
文献类型：
--
作者：
de Vries C;Ruacho G;Kindstedt E;Potempa BA;Potempa J;Klinge B;Lundberg P;Svenungsson E;Lundberg K
越来越多的数据表明，牙周炎与系统性和自身免疫性疾病的风险增加有关，包括心血管疾病、类风湿性关节炎（RA）和系统性红斑狼疮（SLE），并且早期识别这些个体的需求尚未得到满足。随着牙周细菌牙龈卟啉单胞菌（Pg）作为牙周炎的关键驱动因素之一，我们着手调查是否Pg毒力因子精氨酸牙龈卟啉菌蛋白酶（Rgp）的抗体可以作为牙周炎患者的自身免疫和全身性疾病的风险增加的生物标志物。我们在三个研究人群中测量了血清抗Rgp IgG：PAROKRANK（779名心肌梗死（MI）患者; 719名对照），其中557名患有牙周炎，312名与RA/SLE相关的自身抗体阳性; PerioGene North pilot（41名牙周炎患者; 39名对照）;以及SLE病例/对照研究（101名SLE患者; 100名对照）。与对照组相比，重度牙周炎患者抗Rgp IgG水平升高（p < 0.0001）;与自身抗体阴性患者相比，抗瓜氨酸化蛋白抗体（p = 0.04）和抗dsDNA抗体（p = 0.035）阳性患者抗Rgp IgG水平升高;与匹配对照组相比，MI患者抗Rgp IgG水平升高（p = 0.035）。我们的数据支持纵向研究，解决的作用，抗Rgp抗体作为牙周炎患者的生物标志物，在发展自身免疫性RA和SLE的风险增加，以及这些协会的机制。
There is accumulating data suggesting that periodontitis is associated with increased risk of systemic and autoimmune diseases, including cardiovascular disease, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), and there is an unmet need to identify these individuals early. With the periodontal bacteria Porphyromonas gingivalis (Pg) as one of the key drivers of periodontitis, we set out to investigate whether antibodies to Pg virulence factor arginine gingipain (Rgp) could serve as a biomarker for periodontitis patients at increased risk of autoimmunity and systemic disease. We measured serum anti-Rgp IgG in three study populations: PAROKRANK (779 individuals with myocardial infarction (MI); 719 controls), where 557 had periodontitis, and 312 were positive for autoantibodies associated with RA/SLE; the PerioGene North pilot (41 periodontitis; 39 controls); and an SLE case/control study (101 SLE; 100 controls). Anti-Rgp IgG levels were increased in severe periodontitis compared to controls (p < 0.0001), in individuals positive for anti-citrullinated protein antibodies (p = 0.04) and anti-dsDNA antibodies (p = 0.035), compared to autoantibody-negative individuals; and in MI patients versus matched controls (p = 0.035). Our data support longitudinal studies addressing the role of anti-Rgp antibodies as biomarkers for periodontitis patients at increased risk of developing autoimmunity linked to RA and SLE, and mechanisms underpinning these associations.
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影响因子：
3.7
作者：
Boström EA;Kindstedt E;Sulniute R;Palmqvist P;Majster M;Holm CK;Zwicker S;Clark R;Önell S;Johansson I;Lerner UH;Lundberg P
通讯作者：
Lundberg P
影响因子：
3.7
作者：
Gustafsson, Johanna T.;Lindberg, Marie Herlitz;Svenungsson, Elisabet
通讯作者：
Svenungsson, Elisabet
影响因子：
3.5
作者：
Harvey, G. P.;Fitzsimmons, T. R.;Bartold, P. M.
通讯作者：
Bartold, P. M.
影响因子：
158.5
作者：
Arbuckle, MR;McClain, MT;Harley, JB
通讯作者：
Harley, JB
影响因子：
7.3
作者：
Fuggle NR;Smith TO;Kaul A;Sofat N
通讯作者：
Sofat N