Current aspects of formulation efforts and pore lifetime related to microneedle treatment of skin.
Current aspects of formulation efforts and pore lifetime related to microneedle treatment of skin.
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DOI：
10.1517/17425241003663228
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发表时间：
2010-05
影响因子：
6.6
通讯作者：
Stinchcomb AL
中科院分区：
文献类型：
--
作者：
Milewski M;Brogden NK;Stinchcomb AL
微针在经皮药物递送领域的功效已得到充分证实。多项研究表明，通过在角质层中产生微孔来增强皮肤渗透可以大大提高药物的递送速率。然而，微针皮肤预处理不是影响药物转运速率的唯一因素。其他因素，包括药物配方和直肠闭合率也是重要的优化通过这一途径交付。本文旨在重点介绍这些领域已经完成的工作，重点是影响透皮通量的药物配方参数。这篇综述对影响微针增强递送的许多因素进行了评价。大多数结果清楚地表明，微针皮肤预处理本身可能对药物转运具有不同的影响，这取决于所使用的制剂，并且制剂特征对通过未处理皮肤和微针处理皮肤的转运具有不同的影响。报道了几种优化微针增强药物递送的制剂方法，包括共溶剂使用、囊泡、纳米颗粒和凝胶系统。除了影响微针辅助递送的既定因素（微针的几何形状、类型等）外，制剂和孔活力也是必须考虑的关键因素。
The efficacy of microneedles in the area of transdermal drug delivery is well-documented. Multiple studies have shown that enhancement of skin permeation via creation of microscopic pores in the stratum corneum can greatly improve the delivery rates of drugs. However, skin pretreatment with microneedles is not the only factor affecting drug transport rates. Other factors including drug formulation and rate of micropore closure are also important for optimizing delivery via this route. This review aims at highlighting work that has been done in these areas, with an emphasis on drug formulation parameters that affect transdermal flux. This review creates an appreciation for the many factors affecting microneedle-enhanced delivery. Most results clearly indicate that microneedle skin pretreatment by itself may have different effects on drug transport depending on the formulation used, and formulation characteristics have different effects on the transport through untreated skin and microneedle-treated skin. Several formulation approaches are reported to optimize microneedle-enhanced drug delivery, including cosolvent use, vesicular, nanoparticulate and gel systems. In addition to well-established factors that affect microneedle-assisted delivery (geometry, type of microneedles, etc), formulation and pore viability are also critical factors that must be considered.
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影响因子：
46.9
作者：
Karande, P;Jain, A;Mitragotri, S
通讯作者：
Mitragotri, S
影响因子：
2.2
作者：
Bashir, SJ;Chew, AL;Maibach, HI
通讯作者：
Maibach, HI
影响因子：
2.8
作者：
Haq, M. I.;Smith, E.;Birchall, J. C.
通讯作者：
Birchall, J. C.
影响因子：
5.7
作者：
Kaushik, S;Hord, AH;Prausnitz, MR
通讯作者：
Prausnitz, MR
影响因子：
4.6
作者：
Badran, M. M.;Kuntsche, J.;Fahr, A.
通讯作者：
Fahr, A.