Effect of elcatonin versus nonsteroidal anti-inflammatory medications for acute back pain in patients with osteoporotic vertebral fracture: a multiclinic randomized controlled trial
Effect of elcatonin versus nonsteroidal anti-inflammatory medications for acute back pain in patients with osteoporotic vertebral fracture: a multiclinic randomized controlled trial
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降钙素与非甾体类抗炎药物治疗骨质疏松性椎体骨折患者急性背痛的效果：一项多临床随机对照试验
DOI：
10.1007/s00774-016-0765-8
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发表时间：
2017
影响因子：
3.3
通讯作者：
T. Iwaya
中科院分区：
文献类型：
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作者：
N. Endo;K. Fujino;T. Doi;M. Akai;Y. Hoshino;T. Nakano;T. Iwaya
本研究的目的是比较依卡宁注射液和口服非甾体类抗炎药（NSAID）治疗新发椎体压缩性骨折后出现急性腰椎疼痛的骨质疏松症患者的疗效。228例日本女性患者（平均年龄77.3岁），因腰椎骨折引起急性腰痛，随机分为两组。一组患者服用非甾体抗炎药（非甾体抗炎药组），另一组患者每周肌肉注射20单位的依卡宁（依卡宁组）。所有患者从试验开始后6周内接受随访检查。根据日本骨质疏松性疼痛问卷（JQ 22）、Roland-Morris残疾问卷（RDQ）和疼痛强度视觉模拟量表（VAS），结局指标为功能损害水平。统计分析集中在（1）使用线性混合效应模型分析纵向数据的疼痛和功能水平的时间过程和（2）依卡宁注射液的有效性以及平均差值和95%置信区间。随着时间的推移，各组的JQ 22、RDQ和VAS评分（效应值> 0.4）的初始值与干预后值（4周和6周）之间存在显著差异。在第4周和第6周时，依降钙素组和NSAID组在JQ 22的各项测量中的平均差异分别为−4.8和−8.3，RDQ为−1.3和−2.6，VAS为−11.3和−11.5，转换为依降钙素。每周一次依卡宁注射比NSAID更有效地治疗急性腰椎疼痛和改善日本女性腰椎骨折的活动性。
The aim of this study was to compare the efficacy of elcatonin injections and oral nonsteroidal anti-inflammatory drugs (NSAIDs) for patients with osteoporosis who have acute lumbar pain after experiencing new vertebral compression fractures. Two hundred twenty-eight Japanese female patients (mean age 77.3 years) with acute lumbar pain from osteoporotic vertebral fractures were randomly divided into two groups. Patients in one group were given an NSAID (NSAIDs group) and patients in the other group were given weekly intramuscular injections of 20 units of elcatonin (elcatonin group). All patients underwent follow-up examinations up to 6 weeks from the start of the trial. Outcome measures were the level of functional impairment according to the Japan Questionnaire for Osteoporotic Pain (JQ22), the Roland–Morris Disability Questionnaire (RDQ), and a visual analog scale (VAS) of pain intensity. Statistical analyses focused on (1) the time course of pain and functional level using linear mixed effects models to analyze the longitudinal data and (2) the effectiveness of elcatonin injection with mean difference values and 95 % confidence intervals. Significant differences were seen over time between the initial values and the postintervention values (4 and 6 weeks) in JQ22, RDQ, and VAS scores (effect sized> 0.4) in each group. The mean differences between the elcatonin group and the NSAIDs group in each measure at 4 and 6 weeks were −4.8 and −8.3 for the JQ22, −1.3 and −2.6 for the RDQ, and −11.3 and −11.5 for the VAS, shifted to elcatonin. Once weekly elcatonin injection was more effective than NSAIDs for treating acute lumbar pain and improving mobility in Japanese women with osteoporotic vertebral fractures.
日本脆性X细胞研究现状
DOI：
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发表时间：
2018
期刊：
影响因子：
--
作者：
Yuji Nakayama;Kaori Adachi;Norifumi Shioda;Hiroyuki Kugoh and Eiji Nanba
通讯作者：
Hiroyuki Kugoh and Eiji Nanba
影响因子：
3.3
作者：
Ito A;Takeda M;Yoshimura T;Komatsu T;Ohno T;Kuriyama H;Matsuda A;Yoshimura M
通讯作者：
Yoshimura M
影响因子：
2.8
作者：
Katae, Yuji;Tanaka, Shinya;Nakamura, Toshitaka
通讯作者：
Nakamura, Toshitaka