Let-7 and miR-200 microRNAs: guardians against pluripotency and cancer progression.
Let-7 and miR-200 microRNAs: guardians against pluripotency and cancer progression.
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DOI：
10.4161/cc.8.6.7907
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发表时间：
2009-03-15
期刊：
影响因子：
--
通讯作者：
Peter ME
中科院分区：
文献类型：
--
作者：
Peter ME
微小RNA作为细胞分化的重要调节因子正在出现，它们的重要性由它们在癌发生过程中经常失调的事实所强调。两个进化上保守的家族let-7和miR-200调节发育过程中的关键分化过程。let-7在癌症中的缺失导致胚胎发生逆转和去分化，并且miR-200已被鉴定为上皮-间充质转化（EMT）的有力调节剂。最近的研究结果将let-7与干细胞维持联系起来，并指出EMT与干细胞形成之间的联系。肿瘤进展的一部分可以被视为进行性去分化（EMT）的连续体，其中细胞在终点具有干细胞样特性。我认为这个过程的步骤是由let-7和miR-200家族成员表达的特定变化驱动的。
Micro (mi)RNAs are emerging as important regulators of cellular differentiation, their importance underscored by the fact that they are often dysregulated during carcinogenesis. Two evolutionary conserved families, let-7 and miR-200, regulate key differentiation processes during development. Loss of let-7 in cancer results in reverse embryogenesis and dedifferentiation, and miR-200 has been identified as a powerful regulator of epithelialto-mesenchymal transition (EMT). Recent findings have connected let-7 with stem cell maintenance and point at a connection between EMT and stem cell formation. A part of tumor progression can be viewed as a continuum of progressive dedifferentiation (EMT) with a cell at the endpoint that has stem cell-like properties. I propose that steps of this process are driven by specific changes in the expression of let-7 and miR-200 family members.
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