Agreement of visual estimation of coronary artery calcium from low-dose CT attenuation correction scans in hybrid PET/CT and SPECT/CT with standard Agatston score.
Agreement of visual estimation of coronary artery calcium from low-dose CT attenuation correction scans in hybrid PET/CT and SPECT/CT with standard Agatston score.
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DOI：
10.1016/j.jacc.2010.05.057
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发表时间：
2010-11-30
影响因子：
24
通讯作者：
Berman, Daniel S.
中科院分区：
文献类型：
--
作者：
Einstein, Andrew J.;Johnson, Lynne L.;Bokhari, Sabahat;Son, Jessica;Thompson, Randall C.;Bateman, Timothy M.;Hayes, Sean W.;Berman, Daniel S.
我们试图评价通过混合PET/CT和SPECT/CT心肌灌注成像（MPI）进行的CT衰减校正（CTAC）扫描对冠状动脉钙（CAC）进行视觉估计的准确性和再现性。在MPI时，混合系统获得用于执行衰减校正的低剂量、非ECG门控CT扫描。以前没有研究过这种CTAC扫描在估计实际CAC（通过标准ECG门控扫描上的Agatston评分（AS）测量）中的效用。研究了来自3个中心的492名接受MPI和CTAC以及标准CAC扫描的患者。在每家临床试验机构，对AS设盲的经验丰富的阅片者审查了CTAC图像，在6级量表上目视估计CAC：将患者分类为估计AS 0、1-9、10-99、100-300、400-999或≥1000。视觉估计CAC（VECAC）对CTAC和AS之间的协议，测量标准偏差并转换为相同的规模，进行了评估，因为是读者之间的协议。虽然CTAC图像是低剂量和非门控的，但在VECAC和AS之间观察到高度相关性，63%的VECAC与AS类别相同，93%的VECAC在一个类别内。加权kappa为0.89（95%置信区间为0.88至0.91，p<0.0001）。观察到每个部位、扫描仪类型和性别的高加权kappa统计量。65%的读者报告了相同的分数，93%的读者报告了同一类别的分数。CAC可以通过低剂量CTAC扫描进行视觉评估，与AS高度一致。CTAC扫描应定期评估VECAC。
We sought to evaluate the accuracy and reproducibility of visual estimation of coronary artery calcium (CAC) from CT attenuation correction (CTAC) scans performed for hybrid PET/CT and SPECT/CT myocardial perfusion imaging (MPI). At the time of MPI, hybrid systems obtain a low-dose, non-ECG-gated CT scan that is used to perform attenuation correction. Utility of this CTAC scan in estimating actual CAC as measured by Agatston score (AS) on standard ECG-gated scans has not been previously studied. 492 patients from 3 centers receiving both MPI with CTAC and a standard CAC scan were studied. At each site, experienced readers blinded to AS reviewed CTAC images, visually estimating CAC on a six-level scale: classifying patients as estimated AS of 0, 1-9, 10-99, 100-300, 400-999, or ≥1000. Agreement between visually-estimated CAC (VECAC) on CTAC and AS, measured standardly and converted to the same scale, was evaluated, as was inter-reader agreement. Although CTAC images are low-dose and non-gated, a high degree of association was observed between VECAC and AS, with 63% of VECACs in the same category as the AS category and 93% within one category. Weighted kappa was 0.89 (95% confidence interval 0.88 to 0.91, p<0.0001). High weighted kappa statistics were observed for each site, scanner type, and gender. Readers reported identical scores in 65% of cases and scores within one category in 93%. CAC can be visually assessed from low-dose CTAC scans with high agreement with AS. CTAC scans should be routinely assessed for VECAC.
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影响因子：
--
作者：
Kim, Kwang Pyo;Einstein, Andrew J.;de Gonzalez, Amy Berrington
通讯作者：
de Gonzalez, Amy Berrington
影响因子：
37.8
作者：
Horton, KM;Post, WS;Fishman, EK
通讯作者：
Fishman, EK
DOI：
10.1016/0735-1097(90)90282-t
发表时间：
1990-03-15
影响因子：
24
作者：
AGATSTON, AS;JANOWITZ, WR;DETRANO, R
通讯作者：
DETRANO, R
影响因子：
3.5
作者：
Hamann, M.;Aldridge, M.;Hutton, B. F.
通讯作者：
Hutton, B. F.
影响因子：
5.9
作者：
Horiguchi, Jun;Fukuda, Hiroshi;Ito, Katsuhide
通讯作者：
Ito, Katsuhide