Human Leukocytes in the Active State
Human Leukocytes in the Active State
复制标题
处于活跃状态的人类白细胞
DOI：
10.1007/978-94-009-7585-9_3
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
S. Chien
中科院分区：
文献类型：
--
作者：
G. Schmid;R. Skalak;K. Sung;S. Chien
研究白细胞的流变学特性是一个令人着迷的课题，因为这些细胞可以在两种不同的状态下被观察到。在被动状态下，白细胞呈球形，只有在施加外部应力时才会变形，例如血浆流体应力或附着在基质上的应力。一旦外部应力被去除，电池就会恢复到球形。在微循环中循环或在静脉内皮细胞上滚动的白细胞通常处于被动状态(1，2)。在活跃状态下，白细胞在没有外力作用的情况下自发变形，而不是均匀的静水压力。因此，所需的能量是由电池本身提供的。白细胞形成膜突起(假突起)，导致不规则的细胞形状(3)。在循环中，当白细胞穿过内皮壁时(4)或在趋化梯度(5-7)中迁移时，以及在吞噬过程中(8)，它们会自发变形。
Study of the Theological properties of leukocytes is a fascinating subject, because these cells can be observed in two different states. In the passive state, leukocytes are spherical and they deform only when an external stress is applied, such as plasma fluid stress or an adhesive stress to a substrate. Once the external stress is removed the cell returns to the spherical shape. Leukocytes circulating in the microcirculation or rolling on the venous endothelium are usually in the passive state (1,2). In the active state, leukocytes deform spontaneously without an external force acting on them other than a uniform hydrostatic pressure. Therefore, the required energy is supplied by the cell itself. The leukocytes develop membrane projections (pseudo-pods) which lead to irregular cell shapes (3). In the circulation leukocytes deform spontaneously when they migrate across the endothelial wall (4) or in a chemotactic gradient (5–7), and during phagocytosis (8).
影响因子：
20.3
作者：
G. Schmid-Schönbein;Y. Y. Shih-Y.;S. Chien
通讯作者：
G. Schmid-Schönbein;Y. Y. Shih-Y.;S. Chien