Modeling of trabecular bone and lamina dura following selective alveolar decortication in rats.
Modeling of trabecular bone and lamina dura following selective alveolar decortication in rats.
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DOI：
10.1902/jop.2008.080024
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发表时间：
2008-09
影响因子：
4.3
通讯作者：
Ferguson DJ
中科院分区：
文献类型：
--
作者：
Sebaoun JD;Kantarci A;Turner JW;Carvalho RS;Van Dyke TE;Ferguson DJ
通过选择性地损伤牙槽骨皮质板来改变吸收和对位之间的平衡，已经成为一种加速牙齿移动的方法，被称为牙周加速成骨正畸。本研究的目的是在一种大鼠模型中，研究肺泡对皮质切除手术的反应随时间和手术损伤的邻近程度的变化。健康成年大鼠36只，左上第一磨牙邻侧，对上颌、颊、舌三种皮质板进行损伤。24只动物在3周、7周或11周时被安乐死。其中一组切除上颌骨，剥离软组织，进行组织形态计量学分析，以研究牙槽海绵和牙周膜(PDL)的建模动力学。用抗酒石酸酸性磷酸酶阳性破骨细胞和破骨前细胞分析分解代谢活性。在30天和51天处死动物后，用荧光活性骨染色法测量合成代谢的作用。为了进一步分析新骨形成，另一组动物被饲喂钙黄绿素荧光染色，并进行非脱钙荧光染色组织学检查。术后3周，手术组的钙化海绵体骨表面明显减少(P<；0.05)，牙周韧带表面较大，破骨细胞数量较多，硬脑膜相对宽度较大。分解代谢活性(破骨细胞计数)和合成代谢活性(聚集率)增加了三倍，钙化海绵减少了两倍，PDL表面增加了两倍。手术对牙槽骨的损伤在术后第3周引起组织周转率显著增加，到术后第11周消退至稳定状态。损伤的影响局限于紧邻脱皮质损伤的区域。选择性牙槽骨脱钙导致牙槽骨海绵组织周转率增加，其活动是局部性的；脱矿-再矿化动力学急剧升级可能是选择性牙槽骨脱皮后牙齿快速移动的生物学机制。
Modifying the balance between resorption and apposition through selectively injuring the cortical plate of the alveolus has been an approach to speed tooth movement and is referred to as periodontally accelerated osteogenic orthodontics. The aim of this study was to investigate the alveolar response to corticotomy as a function of time and proximity to the surgical injury in a rat model. Maxillary buccal and lingual cortical plates were injured in 36 healthy adult rats adjacent to the upper left first molars. Twenty-four animals were euthanized at 3, 7, or 11 weeks. In one group, the maxillae were removed and stripped of soft tissues, and histomorphometric analysis was performed to study alveolar spongiosa and periodontal ligament (PDL) modeling dynamics. Catabolic activity was analyzed with tartrate-resistant acid phosphatase–positive osteoclasts and preosteoclasts. Anabolic actions were measured using a fluorescent vital bone stain series followed by sacrifice at 30 and 51 days. To further analyze the new bone formation, a separate group of animals were fed with calcein fluorescent stain and processed for non-decalcified fluorescent stain histology. At 3 weeks, the surgery group had significantly (P <0.05) less calcified spongiosa bone surface, greater periodontal ligament surface, higher osteoclast number, and greater lamina dura apposition width. The catabolic activity (osteoclast count) and anabolic activity (apposition rate) were three-fold greater, calcified spongiosa decreased by two-fold, and PDL surface increased by two-fold. Surgical injury to the alveolus that induced a significant increase in tissue turnover by week 3 dissipated to a steady state by postoperative week 11. The impact of the injury was localized to the area immediately adjacent to the decortication injury. Selective alveolar decortication induced increased turnover of alveolar spongiosa, and the activity was localized; dramatic escalation of demineralization-remineralization dynamics is the likely biologic mechanism underlying rapid tooth movement following selective alveolar decortication.
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DOI：
10.1016/s0301-0503(75)80022-1
发表时间：
1975-06-01
期刊：
Journal of maxillofacial surgery
影响因子：
--
作者：
Duker, J
通讯作者：
Duker, J
影响因子：
2.8
作者：
BOGOCH, E;GSCHWEND, N;PERREN, S
通讯作者：
PERREN, S
DOI：
10.1016/0030-4220(59)90051-9
发表时间：
1959-04-01
期刊：
Oral surgery, oral medicine, and oral pathology
影响因子：
--
作者：
KOLE, H
通讯作者：
KOLE, H
影响因子：
4.2
作者：
KROOK, L;LUTWAK, L;SHEFFY, BE
通讯作者：
SHEFFY, BE
DOI：
10.1016/0030-4220(59)90153-7
发表时间：
1959-05-01
期刊：
Oral surgery, oral medicine, and oral pathology
影响因子：
--
作者：
KOLE, H
通讯作者：
KOLE, H