Colonic mucosal necrosis following administration of calcium polystryrene sulfonate (Kalimate) in a uremic patient.
Colonic mucosal necrosis following administration of calcium polystryrene sulfonate (Kalimate) in a uremic patient.
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DOI：
10.3346/jkms.2009.24.6.1207
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发表时间：
2009-12
影响因子：
4.5
通讯作者：
Han SR
中科院分区：
文献类型：
--
作者：
Joo M;Bae WK;Kim NH;Han SR
已知结肠坏死是服用Kayexalate（聚苯乙烯磺酸钠）山梨醇后的一种罕见并发症。我们报告一位34岁男性服用Kalimate（聚苯乙烯磺酸钙）后发生结肠粘膜坏死的罕见病例，Kalimate是Kayexalate的类似物，不含山梨醇。在颅内出血的治疗过程中，发生了高钾血症。Kalimate口服给药，并作为灌肠剂悬浮在20%葡萄糖水中治疗高钾血症。在给予Kalimate灌肠剂两天后，患者出现大量便血，乙状结肠镜检查显示直肠和乙状结肠弥漫性结肠粘膜坏死。通过连续两次乙状结肠镜检查对随机结肠活检进行显微镜检查，发现溃疡粘膜上有角状晶体，具有特征性晶体镶嵌图案，与Kayexalate晶体一致。停药后，经保守治疗便血消退。
Colonic necrosis is known as a rare complication following the administration of Kayexalate (sodium polystryrene sulfonate) in sorbitol. We report a rare case of colonic mucosal necrosis following Kalimate (calcium polystryrene sulfonate), an analogue of Kayexalate without sorbitol in a 34-yr-old man. He had a history of hypertension and uremia. During the management of intracranial hemorrhage, hyperkalemia developed. Kalimate was administered orally and as an enema suspended in 20% dextrose water to treat hyperkalemia. Two days after administration of Kalimate enema, he had profuse hematochezia, and a sigmoidoscopy showed diffuse colonic mucosal necrosis in the rectum and sigmoid colon. Microscopic examination of random colonic biopsies by two consecutive sigmoidoscopies revealed angulated crystals with a characteristic crystalline mosaic pattern on the ulcerated mucosa, which were consistent with Kayexalate crystals. Hematochezia subsided with conservative treatment after a discontinuance of Kalimate administration.
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影响因子：
5.6
作者：
Rashid, A;Hamilton, SR
通讯作者：
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DOI：
10.1097/00005373-200108000-00031
发表时间：
2001-08-01
影响因子：
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