Antimicrobial activity of five herbal extracts against multi drug resistant (MDR) strains of bacteria and fungus of clinical origin.
Antimicrobial activity of five herbal extracts against multi drug resistant (MDR) strains of bacteria and fungus of clinical origin.
复制标题
DOI：
10.3390/molecules14020586
复制
发表时间：
2009-02-04
期刊：
影响因子：
--
通讯作者：
Khan AU
中科院分区：
文献类型：
--
作者：
Khan R;Islam B;Akram M;Shakil S;Ahmad A;Ali SM;Siddiqui M;Khan AU
筛选了5种植物粗乙醇提取物对多药耐药菌株大肠杆菌、肺炎克雷伯菌和白色念珠菌的抑菌活性。同时检测了变形链球菌、金黄色葡萄球菌、粪肠球菌、牛链球菌、铜绿假单胞菌、鼠伤寒沙门氏菌、大肠杆菌、肺炎克雷伯菌和白色念珠菌的ATCC菌株。选择对所测抗生素耐药最多的菌株进行抗菌试验。耐多药菌株对尼罗刺槐、香合木和肉桂的抑菌活性敏感，而对阿朱顶和蓝桉提取物的抑菌活性较强。社区获得性感染对这些提取物的敏感性高于医院感染。抗微生物活性最强的植物是尼罗花（MIC范围为9.75 ~ 313µg/ml），而本报告研究的其他粗植物提取物对社区获得性和医院感染的MIC值均高于尼罗花。本研究认为，尼罗单胞杆菌、zeylanicum和S. aromaticum可用于治疗引起医院和社区获得性感染的多重耐药微生物。
Antimicrobial activities of the crude ethanolic extracts of five plants were screened against multidrug resistant (MDR) strains of Escherichia coli, Klebsiella pneumoniae and Candida albicans. ATCC strains of Streptococcus mutans, Staphylococcus aureus, Enterococcus faecalis, Streptococcus bovis, Pseudimonas aeruginosa, Salmonella typhimurium, Escherichia coli, Klebsiella pneumoniae and Candida albicans were also tested. The strains that showed resistance against the maximum number of antibiotics tested were selected for an antibacterial assay. The MDR strains were sensitive to the antimicrobial activity of Acacia nilotica, Syzygium aromaticum and Cinnamum zeylanicum, whereas they exhibited strong resistance to the extracts of Terminalia arjuna and Eucalyptus globulus. Community-acquired infections showed higher sensitivity than the nosocomial infections against these extracts. The most potent antimicrobial plant was A. nilotica (MIC range 9.75-313µg/ml), whereas other crude plant extracts studied in this report were found to exhibit higher MIC values than A. nilotica against community acquired as well as nosocomial infection. This study concludes that A. nilotica, C. zeylanicum and S. aromaticum can be used against multidrug resistant microbes causing nosocomial and community acquired infections.
登录
查看更多内容
影响因子：
5.4
作者：
Bonjar, S
通讯作者：
Bonjar, S
影响因子：
5.4
作者：
BRANTNER, A;GREIN, E
通讯作者：
GREIN, E
影响因子：
2.8
作者：
Dip, EC;Pereira, NA;Fernandes, PD
通讯作者：
Fernandes, PD
影响因子：
5
作者：
Kurokawa, M;Kumeda, CA;Shiraki, K
通讯作者：
Shiraki, K
影响因子：
6.1
作者：
López, P;Sánchez, C;Nerín, C
通讯作者：
Nerín, C