Sustained live poultry market surveillance contributes to early warnings for human infection with avian influenza viruses.
Sustained live poultry market surveillance contributes to early warnings for human infection with avian influenza viruses.
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DOI：
10.1038/emi.2016.75
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发表时间：
2016-08-03
影响因子：
13.2
通讯作者：
Shu, Yuelong
中科院分区：
文献类型：
--
作者：
Fang, Shisong;Bai, Tian;Yang, Lei;Wang, Xin;Peng, Bo;Liu, Hui;Geng, Yijie;Zhang, Renli;Ma, Hanwu;Zhu, Wenfei;Wang, Dayan;Cheng, Jinquan;Shu, Yuelong
自2014年4月以来，中国不同省份报告了人感染高致病性禽流感（HPAI）A（H5N6）病毒的零星病例。2015年6月至2016年1月，在广东省深圳市开展了常规活禽市场（LPM）监测。直到2015年11月才发现H5N6病毒。2015年12月开始，H5N6病毒阳性率明显上升，全市各区的LPM中都检测到病毒。巧合的是，2015年12月底和2016年1月初，深圳有两例有禽类接触史的人间病例出现症状，并被诊断为H5N6阳性。在LPM和患者中收集的环境样本中鉴定出类似的病毒。与先前报道的H5N6病毒不同，本研究检测到了来自H9N2或H7N9病毒的具有6个内部基因的病毒。LPM中H5N6病毒阳性率的增加以及随后的人类感染表明，对禽流感病毒的持续LPM监测为人类感染提供了早期预警。当在LPM监测期间广泛检测到H5N6病毒时，应立即实施关闭LPM等干预措施，以降低人类感染H5N6病毒的风险。
Sporadic human infections with the highly pathogenic avian influenza (HPAI) A (H5N6) virus have been reported in different provinces in China since April 2014. From June 2015 to January 2016, routine live poultry market (LPM) surveillance was conducted in Shenzhen, Guangdong Province. H5N6 viruses were not detected until November 2015. The H5N6 virus-positive rate increased markedly beginning in December 2015, and viruses were detected in LPMs in all districts of the city. Coincidently, two human cases with histories of poultry exposure developed symptoms and were diagnosed as H5N6-positive in Shenzhen during late December 2015 and early January 2016. Similar viruses were identified in environmental samples collected in the LPMs and the patients. In contrast to previously reported H5N6 viruses, viruses with six internal genes derived from the H9N2 or H7N9 viruses were detected in the present study. The increased H5N6 virus-positive rate in the LPMs and the subsequent human infections demonstrated that sustained LPM surveillance for avian influenza viruses provides an early warning for human infections. Interventions, such as LPM closures, should be immediately implemented to reduce the risk of human infection with the H5N6 virus when the virus is widely detected during LPM surveillance.
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影响因子：
6.4
作者：
Wang, Chengmin;Wang, Jing;He, Hongxuan
通讯作者：
He, Hongxuan
DOI：
10.1073/pnas.1422456112
发表时间：
2015-01-13
影响因子：
11.1
作者：
Pu, Juan;Wang, Shuoguo;Webster, Robert G.
通讯作者：
Webster, Robert G.
DOI：
10.1128/genomea.00706-14
发表时间：
2014-09-11
期刊：
Genome announcements
影响因子：
--
作者：
Qi X;Cui L;Yu H;Ge Y;Tang F
通讯作者：
Tang F
影响因子：
11.8
作者：
Wong FY;Phommachanh P;Kalpravidh W;Chanthavisouk C;Gilbert J;Bingham J;Davies KR;Cooke J;Eagles D;Phiphakhavong S;Shan S;Stevens V;Williams DT;Bounma P;Khambounheuang B;Morrissy C;Douangngeun B;Morzaria S
通讯作者：
Morzaria S
DOI：
10.1073/pnas.1019109108
发表时间：
2011-03-08
影响因子：
11.1
作者：
Sun, Yipeng;Qin, Kun;Liu, Jinhua
通讯作者：
Liu, Jinhua