Nutrient control of Drosophila longevity.
Nutrient control of Drosophila longevity.
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DOI：
10.1016/j.tem.2014.02.006
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发表时间：
2014-10
影响因子：
10.9
通讯作者：
Yu, Kweon
中科院分区：
文献类型：
--
作者：
Tatar, Marc;Post, Stephanie;Yu, Kweon
Dietary restriction (DR) extends lifespan of many animals including Drosophila melanogaster. Recent work with flies shows longevity is controlled by the ratio of consumed protein relative to carbohydrates. Since reduced insulin/IGF and TOR signaling increase Drosophila lifespan, these pathways are candidate mediators of DR. This idea, however, has ambiguous experimental support. The Nutritional Geometric Framework, which dissects the impact of nutrient protein relative to carbohydrates, may provide an approach to resolving the roles for these pathways in DR. Nutrient sensing of protein and carbohydrate may occur in the fat body through signals to hypothalamic-like neurons in the fly brain, and thus control secretion of insulin-like peptides that regulate longevity.
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影响因子：
7.8
作者：
Bai H;Kang P;Tatar M
通讯作者：
Tatar M
影响因子：
9.2
作者：
Brogiolo, W;Stocker, H;Hafen, E
通讯作者：
Hafen, E
影响因子：
64.5
作者：
Böhni, R;Riesgo-Escovar, J;Hafen, E
通讯作者：
Hafen, E
DOI：
10.1111/nyas.12212
发表时间：
2013-01-01
期刊：
RESVERATROL AND HEALTH
影响因子：
--
作者：
Barger, Jamie L.
通讯作者：
Barger, Jamie L.
影响因子：
56.9
作者：
Clancy, DJ;Gems, D;Partridge, L
通讯作者：
Partridge, L