Very mild Alzheimer's disease
Very mild Alzheimer's disease
复制标题
非常轻微的阿尔茨海默病
作者：
J. Morris;D. McKeel;M. Storandt;E. Rubin;J. Price;E. Grant;M. Ball;L. Berg
我们比较了10名阿尔茨海默型老年性痴呆非常轻度阶段的受试者的临床病理学数据与4名认知正常受试者的类似研究结果。我们根据10名受试者的报告和经验丰富的临床医生的判断诊断为非常轻度的痴呆。缺陷的记忆，语言和加速的心理表现的一些心理测量，观察这些科目。阿尔茨海默病的组织学标志物，包括神经纤维缠结和老年斑的“弥漫性”和经典亚型，存在于所有10名受试者的新皮层中，但基本上不存在于4名对照组中。这些发现表明，即使是“可疑”的痴呆症也可以诊断为阿尔茨海默病。此外，由于真正正常的衰老可能不伴有新皮质老年斑和神经纤维缠结，这些病变的存在应表明临床未发现的阿尔茨海默病的可能性。
We compare clinicopathologic data from 10 subjects identified in the very mild stage of senile dementia of the Alzheimer type with findings from similar studies in four cognitively normal subjects. We based the diagnosis of very mild dementia in the 10 subjects on informant reports and the judgment of experienced clinicians. Deficits of some psychometric measures of memory, language, and speeded psychomotor performance were observed for these subjects. The histologic markers of Alzheimer's disease, including neurofibrillary tangles and both the “diffuse” and classic subtypes of senile plaques, were present in the neocortex in all 10 subjects but essentially were absent in the four controls. These findings indicate that even “questionable” dementia can be diagnostic for Alzheimer's disease. Furthermore, because truly normal aging may be unaccompanied by neocortical senile plaques and neurofibrillary tangles, the presence of these lesions should suggest the possibility of clinically undetected Alzheimer's disease.
DOI：
10.1016/0013-4694(85)91048-x
发表时间：
1985-01-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
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作者：
COBEN, LA;DANZIGER, W;STORANDT, M
通讯作者：
STORANDT, M