Serum Metabolomic Profiles Associated With Untreated Metabolic Syndrome Patients in the Chinese Population.
Serum Metabolomic Profiles Associated With Untreated Metabolic Syndrome Patients in the Chinese Population.
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中国人群中未经治疗的代谢综合征患者的血清代谢组学特征
DOI：
10.1111/cts.12817
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发表时间：
2020-11
期刊：
影响因子：
--
通讯作者：
Gao B
中科院分区：
文献类型：
--
作者：
Li Y;Wang Y;Zhuang Y;Zhang P;Chen S;Asakawa T;Gao B
代谢组学是研究代谢综合征发病机制的一项重要技术。然而，不同条件下MetS患者的测量值不同。因此，在不同人群和病理生理条件下进行代谢组学实验是必不可少的。我们对中国人群中未经治疗的MetS患者进行了血清代谢组学研究。本研究招募了未经治疗的MetS患者。使用传统的1H核磁共振（NMR）实验，然后进行主成分分析（PCA）和正交偏最小二乘判别分析（OPLS-DA）来测量代谢物。通过检索京都基因和基因组途径数据库百科全书，确定了关键代谢途径。共入组28例MetS患者和30例健康受试者。所有患者均未接受治疗，因为他们不知道或忽视治疗他们的MetS。通过1H NMR，我们鉴定了49种已知物质。在PCA和OPLS-DA之后，与对照组相比，证实了36种代谢物与MetS密切相关; 33种代谢物增加，而3种代谢物减少。重要的是，这些未经治疗的MetS患者血清中发生变化的14种代谢物以前未报告。途径分析揭示了与未处理的MetS相关的前15条代谢途径，其中包括3条氨基酸代谢途径。我们的数据表明，未经治疗的患者表现出更差的病理生理表现，这可能会导致更快的进展MetS。因此，我们建议加强健康教育，以提高公众对MetS的知识，态度和行为。必须立即降低由于不了解和忽视而“未经治疗”的病人的比率。
Metabolomics is a promising technology for elucidating the mechanisms of metabolic syndrome (MetS). However, measurements in patients with MetS under different conditions vary. Metabolomics experiments in different populations and pathophysiological conditions are, therefore, indispensable. We performed a serum metabolomics investigation in untreated patients with MetS in the Chinese population. Untreated patients with MetS were recruited to this study. Metabolites were measured using a traditional 1H nuclear magnetic resonance (NMR) experiment followed by principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS‐DA). Key metabolic pathways were identified by searching the Kyoto Encyclopedia of Genes and Genomes Pathway Database. A total of 28 patients with MetS and 30 healthy subjects were enrolled. All patients were untreated because they were unaware of or neglected to treat their MetS. By 1H NMR, we identified 49 known substances. Following PCA and OPLS‐DA, 36 metabolites were confirmed to be closely associated with MetS compared with the control group; 33 metabolites were increased, whereas 3 metabolites were reduced. Importantly, 14 metabolites that changed in the serum of these untreated patients with MetS were previously unreported. Pathway analysis revealed the top 15 metabolic pathways associated with untreated MetS, which included 3 amino acid metabolic pathways. Our data suggest that untreated patients exhibit a worse pathophysiologic manifestation, which may result in more rapid progression of MetS. Thus, we propose that health education be reinforced to improve the public’s knowledge, attitude, and practice regarding MetS. The rates of “untreated” patients due to unawareness and neglect must be reduced immediately.
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影响因子：
3.7
作者：
Strifler G;Tuboly E;Görbe A;Boros M;Pécz D;Hartmann P
通讯作者：
Hartmann P
影响因子：
3.3
作者：
Purohit, PV;Rocke, DM;Woodruff, DL
通讯作者：
Woodruff, DL
DOI：
10.1152/ajpendo.00630.2012
发表时间：
2013-06-01
影响因子：
5.1
作者：
Lackey, Denise E.;Lynch, Christopher J.;Adams, Sean H.
通讯作者：
Adams, Sean H.
影响因子：
37.8
作者：
de Ferranti, SD;Gauvreau, K;Rifai, N
通讯作者：
Rifai, N
影响因子：
4.4
作者：
McClay, Joseph L.;Adkins, Daniel E.;van den Oord, Edwin J. C. G.
通讯作者：
van den Oord, Edwin J. C. G.