Age-related changes in collagen packing of human articular cartilage.
Age-related changes in collagen packing of human articular cartilage.
复制标题
人类关节软骨胶原蛋白堆积与年龄相关的变化。
DOI：
10.1016/0304-4165(94)00134-j
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
R. Schneiderman
中科院分区：
文献类型：
--
作者：
E. Wachtel;A. Maroudas;R. Schneiderman
我们使用x射线散射技术来确定人类关节软骨原纤维中胶原蛋白分子的横向堆积是否随年龄而变化。这种变化会影响可用的纤维内体积，从而影响纤维内水的量。对年龄在20岁至90岁之间的捐献者的样本进行了有和没有压缩的测量。我们发现一个弱的，虽然统计上显著倾向于较低密度的胶原蛋白包装在原生组织作为一个功能的年龄。然而，在压力作用下堆积密度的增加并不会随着年龄的增长而改变，而去除蛋白聚糖分子的关节软骨的堆积密度同样也不依赖于年龄。我们的数据表明，纤维内水的少量增加不足以解释老年供体样本中纤维直径的增加。
We have used X-ray scattering techniques to determine if the lateral packing of collagen molecules in the fibrils of human articular cartilage changes with age. Such changes would affect the available intrafibrillar volume and consequently the amount of intrafibrillar water. Measurements were made both in the presence and absence of compression on samples from donors aged 20 to 90 years. We find a weak though statistically significant tendency towards less dense collagen packing in native tissue as a function of age. However, the increase in packing density in response to pressure does not change with age, and the packing density in articular cartilage from which the proteoglycan molecules have been removed is similarly not age-dependent. The small increase in intrafibrillar water indicated by our data is insufficient to explain the reported increase in fibril diameter in samples from aged donors.
关于骨和软骨的胶原原纤维的适应性结构。
影响因子：
2.4
作者：
Volpi,M;Katz,EP
通讯作者：
Katz,EP
影响因子：
5.6
作者：
TANAKA, S;AVIGAD, G;EIKENBERRY, EF
通讯作者：
EIKENBERRY, EF