Seabuckthorn Reverses High-Fat-Diet-Induced Obesity and Enhances Fat Browning via Activation of AMPK/SIRT1 Pathway.
Seabuckthorn Reverses High-Fat-Diet-Induced Obesity and Enhances Fat Browning via Activation of AMPK/SIRT1 Pathway.
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沙棘通过激活 AMPK/SIRT1 途径逆转高脂肪饮食引起的肥胖并增强脂肪褐变。
DOI：
10.3390/nu14142903
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发表时间：
2022-07-15
期刊：
影响因子：
5.9
通讯作者：
Zhao, Junxing
中科院分区：
文献类型：
--
作者：
Wang, Yu;Gao, Xuyang;Chen, Xiaoyou;Li, Qiang;Li, Xinrui;Zhao, Junxing
沙棘具有多种生物活性成分，具有多种积极的药理活性。本试验旨在确定摄入沙棘粉对高脂饮食（HFD）诱导的小鼠肥胖预防的影响。结果表明，沙棘粉摄入量降低体重，脂肪量和循环脂质水平，并提高胰岛素敏感性HFD喂养的小鼠。此外，膳食沙棘粉可减轻HFD诱导的肝脂肪变性和肝脏脂质蓄积。此外，沙棘在白色脂肪组织（WAT）中表现出明显的抗炎能力，通过调节炎症相关细胞因子的丰度，如白细胞介素4、6和10;肿瘤坏死因子α;和干扰素-γ。更重要的是，膳食沙棘粉促进了BAT中的产热程序，并诱导HFD喂养小鼠iWAT中米色脂肪细胞的形成。有趣的是，我们发现沙棘粉有效地恢复了HFD喂养小鼠BAT和iWAT中的AMPK和SIRT 1活性。总的来说，这些结果加强了沙棘粉作为营养干预策略的应用，通过促进BAT中的产热作用和改善WAT中的米色脂肪细胞形成来预防肥胖和相关代谢疾病。
Seabuckthorn possesses various bioactive compounds and exhibits several positive pharmacological activities. The present trial aims to determine the effect of seabuckthorn powder intake on high-fat diet (HFD)-induced obesity prevention in mice. The results suggest that seabuckthorn powder intake decreased body weight, fat mass, and circulating lipid levels, and improved insulin sensitivity in HFD-fed mice. Moreover, dietary seabuckthorn powder alleviated hepatic steatosis and hepatic lipid accumulation induced by the HFD. Furthermore, seabuckthorn exhibited obvious anti-inflammatory capacity in white adipose tissue (WAT) by regulating the abundance of inflammation-related cytokines, such as interleukins 4, 6, and 10; tumor necrosis factor α; and interferon-γ. More importantly, dietary seabuckthorn powder promoted a thermogenic program in BAT and induced beige adipocyte formation in iWAT in HFD-fed mice. Interestingly, we found that seabuckthorn powder effectively restored AMPK and SIRT1 activities in both BAT and iWAT in HFD-fed mice. Collectively, these results potentiate the application of seabuckthorn powder as a nutritional intervention strategy to prevent obesity and related metabolic diseases by promoting thermogenesis in BAT and improving beige adipocyte formation in WAT.
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影响因子：
30.5
作者：
Chung KJ;Chatzigeorgiou A;Economopoulou M;Garcia-Martin R;Alexaki VI;Mitroulis I;Nati M;Gebler J;Ziemssen T;Goelz SE;Phieler J;Lim JH;Karalis KP;Papayannopoulou T;Blüher M;Hajishengallis G;Chavakis T
通讯作者：
Chavakis T
影响因子：
5.9
作者：
Kwon EY;Lee J;Kim YJ;Do A;Choi JY;Cho SJ;Jung UJ;Lee MK;Park YB;Choi MS
通讯作者：
Choi MS
影响因子：
29
作者：
Mottillo EP;Desjardins EM;Crane JD;Smith BK;Green AE;Ducommun S;Henriksen TI;Rebalka IA;Razi A;Sakamoto K;Scheele C;Kemp BE;Hawke TJ;Ortega J;Granneman JG;Steinberg GR
通讯作者：
Steinberg GR
影响因子：
82.9
作者：
Czech MP
通讯作者：
Czech MP
DOI：
10.1016/j.ecl.2016.04.010
发表时间：
2016-09
影响因子：
4.5
作者：
Mulya, Anny;Kirwan, John P.
通讯作者：
Kirwan, John P.