Alterations in epithelial and mesenchymal intestinal gene expression during doxorubicin-induced mucositis in mice.
Alterations in epithelial and mesenchymal intestinal gene expression during doxorubicin-induced mucositis in mice.
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DOI：
10.1007/s10620-006-9174-5
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发表时间：
2007-08
影响因子：
3.1
通讯作者：
Einerhand, Alexandra W. C.
中科院分区：
文献类型：
--
作者：
de Koning, Barbara A. E.;Lindenbergh-Kortleve, Dicky J.;Pieters, Rob;Buller, Hans A.;Renes, Ingrid B.;Einerhand, Alexandra W. C.
在当前的研究中，我们旨在深入了解多柔比星（DOX）诱导的小鼠粘膜炎期间上皮-间质串扰和祖细胞室调节。DOX治疗后各天收集肠段。dox诱导的第1-2天的损伤表现为上皮细胞增殖和凋亡增加，上皮分化标志物表达减少。同时，t细胞因子-4 （TCF4）水平升高，上皮分化促进因子骨形态发生蛋白-4 （BMP4）水平降低。在严重损伤期间（第3天），BMP4水平显著升高，与上皮细胞增殖呈负相关。同时，上皮分化标志物的表达再次升高。在第7天，BMP4水平下调，而上皮分化标志物和TCF4水平再次正常化。这些数据表明，在对dox诱导的损伤的反应中，BMP4和TCF4以这样一种方式被调节，从而部分地保持了祖细胞室的稳态。
In the current study we aimed to gain insight into epithelial-mesenchymal cross-talk and progenitor compartment modulation during doxorubicin (DOX)-induced mucositis in mice. Intestinal segments were collected on various days after DOX treatment. DOX-induced damage at day 1–2 was characterized by increased epithelial proliferation and apoptosis and a decrease in the expression of epithelial differentiation markers. Concurrently, T-cell factor-4 (TCF4) levels increased and the epithelial differentiation enhancing factor, bone morphogenic protein-4 (BMP4), decreased. During severe damage (day 3), BMP4 levels were significantly increased, which inversely correlated with epithelial proliferation. At the same time, the expression of the epithelial differentiation markers was increasing again. At day 7, BMP4 levels were down-regulated, while the levels of the epithelial differentiation markers and TCF4 were normalized again. These data suggest that in response to DOX-induced damage, BMP4 and TCF4 are modulated in such a way that homeostasis of the progenitor compartment is partly preserved.
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DOI：
10.1111/j.1749-6632.1998.tb11107.x
发表时间：
1998-01-01
期刊：
INTESTINAL PLASTICITY IN HEALTH AND DISEASE
影响因子：
--
作者：
Kedinger, M;Duluc, I;Freund, JN
通讯作者：
Freund, JN
DOI：
10.1083/jcb.200311021
发表时间：
2004-07-05
期刊：
The Journal of cell biology
影响因子：
--
作者：
Blache P;van de Wetering M;Duluc I;Domon C;Berta P;Freund JN;Clevers H;Jay P
通讯作者：
Jay P
DOI：
10.1111/j.1524-4725.1981.tb00208.x
发表时间：
1981-01-01
期刊：
JOURNAL OF DERMATOLOGIC SURGERY AND ONCOLOGY
影响因子：
--
作者：
LOCKHART, PB;SONIS, ST
通讯作者：
SONIS, ST
影响因子：
8.8
作者：
Ijiri, K;Potten, C S
通讯作者：
Potten, C S
影响因子：
3.1
作者：
Martin, Miguel;Garcia-Donas, Jesus;Diaz-Rubio, Eduardo
通讯作者：
Diaz-Rubio, Eduardo