Neural correlates supporting sensory discrimination after left hemisphere stroke.
Neural correlates supporting sensory discrimination after left hemisphere stroke.
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DOI：
10.1016/j.brainres.2012.03.060
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发表时间：
2012-06-15
期刊：
影响因子：
2.9
通讯作者：
Nichols-Larsen DS
中科院分区：
文献类型：
--
作者：
Borstad A;Schmalbrock P;Choi S;Nichols-Larsen DS
近一半的中风患者感觉辨别能力受损，然而，支持中风后感觉功能的神经结构尚未被描述。 1) 评估初级体感 (S1) 皮层在中风后感觉辨别中的作用；2) 确定中风后感觉辨别与上丘脑辐射 (sSTR) 感觉成分结构完整性之间的关系。 10 名健康成年人和 10 名左半球中风患者参加了研究。中风参与者完成了感觉辨别测试。功能磁共振成像是在右手感觉辨别能力受损时进行的。使用扩散张量纤维束成像对 sSTR 的分数各向异性和体积进行量化。 60% 的左侧中风参与者的感觉辨别能力受损。左侧 (S1) 的峰值激活与感觉辨别能力无关，而中风后受试者的激活分布更加明显，顶叶皮层的峰值激活与辨别能力呈正相关 (r=.70，p=.023)。中风参与者的皮层激活与对照组参与者显着不同的唯一大脑区域是楔前叶。对中风参与者的楔前叶感兴趣区域的分析揭示了峰值激活与感觉辨别能力之间的正相关性（r=.77，p=.008）。 sSTR 分数各向异性的 L/R 比率也与右手感觉辨别相关（r=.69，p=.027）。楔前叶皮质、分布式顶叶活动和 sSTR 的微观结构支持左半球中风后的感觉辨别。
Nearly half of stroke patients have impaired sensory discrimination, however, the neural structures that support post-stroke sensory function have not been described. 1) To evaluate the role of the primary somatosensory (S1) cortex in post-stroke sensory discrimination and 2) To determine the relationship between post-stroke sensory discrimination and structural integrity of the sensory component of the superior thalamic radiation (sSTR). 10 healthy adults and 10 individuals with left hemisphere stroke participated. Stroke participants completed sensory discrimination testing. An fMRI was conducted during right, impaired hand sensory discrimination. Fractional anisotropy and volume of the sSTR were quantified using diffusion tensor tractography. Sensory discrimination was impaired in 60% of participants with left stroke. Peak activation in the left (S1) did not correlate with sensory discrimination ability, rather a more distributed pattern of activation was evident in post-stroke subjects with a positive correlation between peak activation in the parietal cortex and discrimination ability (r=.70, p=.023). The only brain region in which stroke participants had significantly different cortical activation than control participants was the precuneus. Region of interest analysis of the precuneus across stroke participants revealed a positive correlation between peak activation and sensory discrimination ability (r=.77, p=.008). The L/R ratio of sSTR fractional anisotropy also correlated with right hand sensory discrimination (r=.69, p=.027). Precuneus cortex, distributed parietal lobe activity, and microstructure of the sSTR support sensory discrimination after left hemisphere stroke.
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