Physical activity and the risk of abdominal aortic aneurysm: a systematic review and meta-analysis of prospective studies.
Physical activity and the risk of abdominal aortic aneurysm: a systematic review and meta-analysis of prospective studies.
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DOI：
10.1038/s41598-020-76306-9
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发表时间：
2020-12-18
影响因子：
4.6
通讯作者：
Riboli E
中科院分区：
文献类型：
--
作者：
Aune D;Sen A;Kobeissi E;Hamer M;Norat T;Riboli E
体力活动与腹主动脉瘤风险之间的关联与一些报告风险降低的研究不一致，而其他研究则没有发现关联。我们对前瞻性研究进行了系统回顾和荟萃分析，以量化这种关联。检索了截至2020年10月3日的PubMed和Embase数据库。如果前瞻性研究报告了与体力活动相关的腹主动脉瘤的校正相对风险（RR）估计值和95%置信区间（CI），则纳入前瞻性研究。使用随机效应模型估计总结RR（95% CI）。纳入了9项前瞻性研究（2073例病例，409，732例受试者）。高与低体力活动的汇总RR为0.70（95% CI：0.56-0.87，I2 = 58%），每20代谢当量任务（MET）小时/周活动增加为0.84（95% CI：0.74-0.95，I2 = 59%，n = 6）。虽然非线性检验不显著（p = 0.09），但当体力活动水平从0增加到约20-25 MET小时/周时，相关性似乎比更高水平时更强。目前的荟萃分析表明，较高的体力活动可能会降低腹主动脉瘤的风险，但是，需要进一步的研究来阐明不同亚型和活动强度与腹主动脉瘤风险之间的剂量反应关系。
The association between physical activity and risk of abdominal aortic aneurysm has been inconsistent with some studies reporting a reduced risk while others have found no association. We conducted a systematic review and meta-analysis of prospective studies to quantify the association. PubMed and Embase databases were searched up to 3 October 2020. Prospective studies were included if they reported adjusted relative risk (RR) estimates and 95% confidence intervals (CIs) of abdominal aortic aneurysm associated with physical activity. Summary RRs (95% CIs) were estimated using a random effects model. Nine prospective studies (2073 cases, 409,732 participants) were included. The summary RR for high vs. low physical activity was 0.70 (95% CI: 0.56–0.87, I2 = 58%) and per 20 metabolic equivalent task (MET)-hours/week increase of activity was 0.84 (95% CI: 0.74–0.95, I2 = 59%, n = 6). Although the test for nonlinearity was not significant (p = 0.09) the association appeared to be stronger when increasing the physical activity level from 0 to around 20–25 MET-hours/week than at higher levels. The current meta-analysis suggest that higher physical activity may reduce the risk of abdominal aortic aneurysm, however, further studies are needed to clarify the dose–response relationship between different subtypes and intensities of activity and abdominal aortic aneurysm risk.
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影响因子：
5.4
作者：
Cornelissen VA;Smart NA
通讯作者：
Smart NA
影响因子：
5
作者：
GREENLAND, S;LONGNECKER, MP
通讯作者：
LONGNECKER, MP
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
3.3
作者：
Gibson, Christine;Nielsen, Cory;Esfandiarei, Mitra
通讯作者：
Esfandiarei, Mitra
影响因子：
--
作者：
GOLDBERG, RJ;BURCHFIEL, CM;YANO, K
通讯作者：
YANO, K