Pulmonary arterial pressure and plasma concentration of atrial natriuretic factor (ANF) in patients with heart disease.
Pulmonary arterial pressure and plasma concentration of atrial natriuretic factor (ANF) in patients with heart disease.
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心脏病患者的肺动脉压和心房钠尿因子（ANF）血浆浓度。
DOI：
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
H. Matsuo
中科院分区：
文献类型：
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作者：
T. Kokubu;A. Nagae;K. Hiwada;Y. Kazatani;T. Joh;H. Matsuo
为探讨心房利钠因子(ANF)释放的控制因素，对34例心脏病心导管术患者外周血心钠素(ANF)浓度进行了分析。血浆心钠素浓度与肺动脉压呈显著正相关(收缩压r=0.87；舒张压r=0.75；平均值r=0.85；P均<0.001)。血浆心钠素浓度与右室收缩压(r=0.001.86，p<0.0 5)、肺毛细血管嵌压(r=0.5 0，p<0.0 1)、平均右房压(r=0.39，p<0.0 5)呈显著正相关。血浆ANF浓度与每搏输出量指数呈弱而显著的负相关(r=-0.43，p<0.05)。血浆ANF浓度与平均肺动脉压的相关系数显著高于血浆ANF浓度与肺毛细血管楔压、血浆ANF浓度与平均右心房压的相关系数(P<0.05和P<0.01)。在10例二尖瓣病变患者中，血浆ANF浓度也与肺动脉压显著相关(收缩压r=0.80；舒张压r=0.82；平均r=0.82；P均<0.01)。这些结果提示，肺动脉压可能在心房肌细胞释放心钠素的机制中起重要作用。
To study the factors controlling the release of atrial natriuretic factor (ANF), we analyzed the peripheral plasma ANF concentration in 34 patients with heart disease who underwent cardiac catheterization. A significant positive correlation between plasma ANF concentration and pulmonary arterial pressure (systolic, r = 0.87; diastolic, r = 0.75; mean, r = 0.85; each p less than 0.001) was found in all the patients examined. There were significant positive correlations between plasma ANF concentration and systolic right ventricular pressure (r = 0.86, p less than 0.001), pulmonary capillary wedge pressure (r = 0.50, p less than 0.01) and mean right atrial pressure (r = 0.39, p less than 0.05). A weak but significant negative correlation was found between plasma ANF concentration and stroke volume index (r = -0.43, p less than 0.05). The correlation coefficient between plasma ANF concentration and mean pulmonary arterial pressure was significantly stronger than those between plasma ANF concentration and pulmonary capillary wedge pressure, and between plasma ANF concentration and mean right atrial pressure (p less than 0.05 and p less than 0.01, respectively). In 10 patients with mitral valvular disease, significant correlations with plasma ANF concentration were also found for pulmonary arterial pressure (systolic, r = 0.80; diastolic, r = 0.82; mean, r = 0.82; each p less than 0.01). These findings suggest that pulmonary arterial pressure may play an important role in the mechanism of release of ANF from atrial cardiocytes.
通过心房扩张从大鼠心肺制剂中释放钠尿因子。
DOI：
10.1152/ajpregu.1984.247.6.r1093
发表时间：
1984
期刊：
The American journal of physiology
影响因子：
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作者：
Dietz,JR
通讯作者：
Dietz,JR