Localization of dense intracranial electrode arrays using magnetic resonance imaging.
Localization of dense intracranial electrode arrays using magnetic resonance imaging.
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DOI：
10.1016/j.neuroimage.2012.06.039
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发表时间：
2012-10-15
期刊：
影响因子：
5.7
通讯作者：
Thesen, Thomas
中科院分区：
文献类型：
--
作者：
Yang, Andrew I.;Wang, Xiuyuan;Doyle, Werner K.;Halgren, Eric;Carlson, Chad;Belcher, Thomas L.;Cash, Sydney S.;Devinsky, Orrin;Thesen, Thomas
关键词：
颅内电极阵列通常用于难治性癫痫患者的术前评估，并且由于其高空间和时间分辨率，来自这些电极的记录已越来越多地用于人类认知神经生理学。对于研究人员和临床医生来说，定位电极位置相对于受试者特定的神经解剖结构至关重要。在许多中心，植入后MRI用于电极检测，因为其对手术并发症的敏感性更高，并且没有辐射。然而，每个电极周围的磁化率伪影阻止了对单个电极的明确检测，尤其是那些嵌入密集网格阵列内的电极。在这里，我们提出了一种有效的方法来准确定位颅内电极阵列的植入前和植入后的MR图像，结合阵列几何形状和个人的皮质表面的基础上。电极相对于个体患者的重建皮质表面的潜在脑回解剖结构直接可视化。该方法的确认显示了定位电极位置的高空间精度（8名患者的271个电极的平均值为0.96 mm±0.81 mm）。最少的用户输入、较短的处理时间和无辐射成像的利用是将颅内电极阵列的定量准确定位与MRI结合用于研究和临床目的的强烈动机。与标准脑图谱的共配准进一步允许受试者间比较以及颅内EEG结果与更大范围的神经影像学文献的关系。
Intracranial electrode arrays are routinely used in the pre-surgical evaluation of patients with medically refractory epilepsy, and recordings from these electrodes have been increasingly employed in human cognitive neurophysiology due to their high spatial and temporal resolution. For both researchers and clinicians, it is critical to localize electrode positions relative to the subject-specific neuroanatomy. In many centers, a post-implantation MRI is utilized for electrode detection because of its higher sensitivity for surgical complications and the absence of radiation. However, magnetic susceptibility artifacts surrounding each electrode prohibit unambiguous detection of individual electrodes, especially those that are embedded within dense grid arrays. Here, we present an efficient method to accurately localize intracranial electrode arrays based on pre- and post-implantation MR images that incorporates array geometry and the individual's cortical surface. Electrodes are directly visualized relative to the underlying gyral anatomy of the reconstructed cortical surface of individual patients. Validation of this approach shows high spatial accuracy of the localized electrode positions (mean of 0.96 mm±0.81 mm for 271 electrodes across 8 patients). Minimal user input, short processing time, and utilization of radiation-free imaging are strong incentives to incorporate quantitatively accurate localization of intracranial electrode arrays with MRI for research and clinical purposes. Co-registration to a standard brain atlas further allows inter-subject comparisons and relation of intracranial EEG findings to the larger body of neuroimaging literature.
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