Localization of neurosurgically implanted electrodes via photograph-MRI-radiograph coregistration.
Localization of neurosurgically implanted electrodes via photograph-MRI-radiograph coregistration.
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DOI：
10.1016/j.jneumeth.2008.06.028
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发表时间：
2008-09-15
影响因子：
3
通讯作者：
Nagarajan, Srikantan S.
中科院分区：
文献类型：
--
作者：
Dalal, Sarang S.;Edwards, Erik;Kirsch, Heidi E.;Barbaro, Nicholas M.;Knight, Robert T.;Nagarajan, Srikantan S.
关键词：
颅内脑电(IEEG)是药物难治性癫痫的临床指征，是发展神经假体的一种很有前途的方法。这些录音也为认知神经科学研究提供了有价值的数据。IEEG电极的准确定位对于评估电极下指示正常或病理活动的特定大脑区域以及将研究结果与神经成像和损伤研究相关联至关重要。然而，电极通常被藏在开颅手术的边缘下，通过毛刺孔插入，或者放置在大脑深处，在那里它们的位置无法通过视觉或神经导航系统进行验证。我们表明，现有的一种方法，即术后CT与术前MRI的配准，可能会导致误差超过1厘米。我们提出了一种新的方法来定位iEEG电极，使用常规获取的外科照片、X射线照片和磁共振成像(MRI)扫描。已知的控制点被用来计算连接不同图像集的投影变换，最终允许定位隐藏的电极，此外还改进了手动配准的可见电极的位置。由于该技术不需要在不同图像模式之间进行任何校准，因此它可以应用于现有的图像数据库。最终的结果是在患者的磁共振成像上的一组电极位置，产生相对于个体解剖上的脑沟和脑回地标的位置，以及MNI坐标。我们在8名癫痫患者身上展示了我们的方法的结果，这些患者植入了横跨左半球的电极网格。
Intracranial electroencephalography (iEEG) is clinically indicated for medically refractory epilepsy and is a promising approach for developing neural prosthetics. These recordings also provide valuable data for cognitive neuroscience research. Accurate localization of iEEG electrodes is essential for evaluating specific brain regions underlying the electrodes that indicate normal or pathological activity, as well as for relating research findings to neuroimaging and lesion studies. However, electrodes are frequently tucked underneath the edge of a craniotomy, inserted via a burr hole, or placed deep within the brain, where their locations cannot be verified visually or with neuronavigational systems. We show that one existing method, registration of postimplant CT with preoperative MRI, can result in errors exceeding 1 cm. We present a novel method for localizing iEEG electrodes using routinely acquired surgical photographs, X-ray radiographs, and magnetic resonance imaging (MRI) scans. Known control points are used to compute projective transforms that link the different image sets, ultimately allowing hidden electrodes to be localized, in addition to refining the location of manually registered visible electrodes. As the technique does not require any calibration between the different image modalities, it can be applied to existing image databases. The final result is a set of electrode positions on the patient’s rendered MRI yielding locations relative to sulcal and gyral landmarks on individual anatomy, as well as MNI coordinates. We demonstrate the results of our method in eight epilepsy patients implanted with electrode grids spanning the left hemisphere.
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DOI：
10.1109/tnsre.2006.875536
发表时间：
2006-06-01
影响因子：
4.9
作者：
Leuthardt, Eric C.;Miller, Kai J.;Ojemann, Jeffrey G.
通讯作者：
Ojemann, Jeffrey G.
影响因子：
64.8
作者：
Hochberg, Leigh R.;Serruya, Mijail D.;Donoghue, John P.
通讯作者：
Donoghue, John P.
影响因子：
1.3
作者：
FOX, PT;PERLMUTTER, JS;RAICHLE, ME
通讯作者：
RAICHLE, ME
影响因子：
4.7
作者：
Hunter, JD;Hanan, DM;Towle, VL
通讯作者：
Towle, VL
影响因子：
4.8
作者：
Mahvash, Mehran;Koenig, Roy;Schaller, Karl
通讯作者：
Schaller, Karl